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Abstract：
OBJECTIVE: Evaluate which factors are involved in the increased rate of mosaicism in embryos.
METHODS: A systematic review and meta-analysis was performed. After an exhaustive search of the literature, a total of seven papers were included in the analysis. In addition, data collected from IVF cycles performed in our fertility clinic were also analysed. Day of biopsy, embryo quality, maternal and paternal age and seminal quality were the chosen factors to be studied.
RESULTS: The results of the meta-analysis show that neither embryo quality nor seminal quality were related to mosaic embryo rate (OR: 1.09; 95% CI: 0.94-1.28 and OR: 1.10; 95% CI: 0.87-1.37, respectively). A positive association was observed for the variable \"biopsy day\" with embryos biopsied at day 6 or 7 having the highest rate of mosaicism (OR: 1.06; 95% CI: 1.01-1.11). In opposite to what happens with aneuploidy rate, which increases with maternal age, embryo mosaicism is higher in younger women (<34 years) rather than in older ones (≥34 years) (OR: 0.95; 95% CI: 0.92-0.98). However, for the \"paternal age\" factor, no association with mosaicism was found (OR: 1.04; 95% CI: 0.90-1.21).
CONCLUSIONS: With the present study, we can conclude that the factors related to the presence of mosaicism in embryos are the embryo biopsy day and maternal age. The rest of the studied factors showed no significant relationship with mosaicism. These results are of great importance as knowing the possible causes leading to mosaicism helps to improve the clinical results of reproductive treatments.
METHODS: A systematic review and meta-analysis was performed. After an exhaustive search of the literature, a total of seven papers were included in the analysis. In addition, data collected from IVF cycles performed in our fertility clinic were also analysed. Day of biopsy, embryo quality, maternal and paternal age and seminal quality were the chosen factors to be studied.
RESULTS: The results of the meta-analysis show that neither embryo quality nor seminal quality were related to mosaic embryo rate (OR: 1.09; 95% CI: 0.94-1.28 and OR: 1.10; 95% CI: 0.87-1.37, respectively). A positive association was observed for the variable \"biopsy day\" with embryos biopsied at day 6 or 7 having the highest rate of mosaicism (OR: 1.06; 95% CI: 1.01-1.11). In opposite to what happens with aneuploidy rate, which increases with maternal age, embryo mosaicism is higher in younger women (<34 years) rather than in older ones (≥34 years) (OR: 0.95; 95% CI: 0.92-0.98). However, for the \"paternal age\" factor, no association with mosaicism was found (OR: 1.04; 95% CI: 0.90-1.21).
CONCLUSIONS: With the present study, we can conclude that the factors related to the presence of mosaicism in embryos are the embryo biopsy day and maternal age. The rest of the studied factors showed no significant relationship with mosaicism. These results are of great importance as knowing the possible causes leading to mosaicism helps to improve the clinical results of reproductive treatments.
摘要：
目的：评估哪些因素参与胚胎镶嵌率的增加。
方法：进行系统评价和荟萃分析。经过详尽的文献搜索，共有七篇论文被纳入分析。此外,我们还分析了在我们的生育诊所进行的IVF周期收集的数据.活检当天，胚胎质量,母亲和父亲的年龄和精液质量是要研究的选择因素。
结果：荟萃分析结果表明，胚胎质量和精液质量均与镶嵌胚率无关（OR：1.09；95％CI：0.94-1.28和OR：1.10；95％CI：0.87-1.37）。变量“活检日”与第6或7天活检的胚胎镶嵌率最高（OR：1.06；95％CI：1.01-1.11）呈正相关。与非整倍体率发生的情况相反，随着产妇年龄的增长，较年轻女性(<34岁)的胚胎镶嵌性高于老年女性(≥34岁)(OR:0.95;95%CI:0.92-0.98).然而,对于“父亲年龄”因素，未发现与镶嵌性相关(OR:1.04;95%CI:0.90-1.21).
结论：根据本研究，我们可以得出结论，与胚胎中镶嵌性的存在有关的因素是胚胎活检日和母体年龄。其余研究因素与镶嵌性没有显着关系。这些结果非常重要，因为了解导致镶嵌的可能原因有助于改善生殖治疗的临床结果。
方法：进行系统评价和荟萃分析。经过详尽的文献搜索，共有七篇论文被纳入分析。此外,我们还分析了在我们的生育诊所进行的IVF周期收集的数据.活检当天，胚胎质量,母亲和父亲的年龄和精液质量是要研究的选择因素。
结果：荟萃分析结果表明，胚胎质量和精液质量均与镶嵌胚率无关（OR：1.09；95％CI：0.94-1.28和OR：1.10；95％CI：0.87-1.37）。变量“活检日”与第6或7天活检的胚胎镶嵌率最高（OR：1.06；95％CI：1.01-1.11）呈正相关。与非整倍体率发生的情况相反，随着产妇年龄的增长，较年轻女性(<34岁)的胚胎镶嵌性高于老年女性(≥34岁)(OR:0.95;95%CI:0.92-0.98).然而,对于“父亲年龄”因素，未发现与镶嵌性相关(OR:1.04;95%CI:0.90-1.21).
结论：根据本研究，我们可以得出结论，与胚胎中镶嵌性的存在有关的因素是胚胎活检日和母体年龄。其余研究因素与镶嵌性没有显着关系。这些结果非常重要，因为了解导致镶嵌的可能原因有助于改善生殖治疗的临床结果。
