PDF(Pubmed)
Abstract：
UNASSIGNED: Colorectal cancer (CRC) is the third most common malignant tumor in the world. The morbidity and mortality rates in Western countries have decreased, but they are still on the rise in China. C10orf90 is associated with a variety of cancers, but the correlation between C10orf90 and CRC is not yet known.
UNASSIGNED: A total of 1,339 subjects were randomly enrolled in our study. After extracting their DNA, three single-nucleotide polymorphisms (SNPs) of C10orf90 were genotyped to analyze the potential relationship between these variants and CRC risk. PLINK software packages (version 1.07) were used to evaluate multiple genetic models by calculating the odds ratio (OR) and 95% confidence interval (95% CI). The best SNP-SNP interaction model was defined by the multifactor dimensionality reduction (MDR) analysis.
UNASSIGNED: C10orf90 rs12412320 was significantly associated with CRC risk (p = 0.006) and might be associated with the lower CRC risk (OR: 0.78; 95% CI: 0.65-0.93). The relationship of rs12412320 with lower CRC risk was found in people aged >60 years and ≤60 years, women, non-smokers, or non-drinkers. Rs11245008 in people aged ≤60 years and rs11245007 among men had a higher CRC susceptibility. Rs12412320 was related to the lower risk of advanced stages (III/IV stage), while rs11245007 might be associated with the higher risk of advanced stages (III/IV stage). Moreover, rs12412320 had the most significant relationship with the susceptibility to rectal cancer.
UNASSIGNED: This study is the first to report between C10orf90 gene polymorphisms and CRC risk in Chinese people, which suggests that C10orf90 rs12412320 might play a crucial role in preventing CRC occurrence.
UNASSIGNED: A total of 1,339 subjects were randomly enrolled in our study. After extracting their DNA, three single-nucleotide polymorphisms (SNPs) of C10orf90 were genotyped to analyze the potential relationship between these variants and CRC risk. PLINK software packages (version 1.07) were used to evaluate multiple genetic models by calculating the odds ratio (OR) and 95% confidence interval (95% CI). The best SNP-SNP interaction model was defined by the multifactor dimensionality reduction (MDR) analysis.
UNASSIGNED: C10orf90 rs12412320 was significantly associated with CRC risk (p = 0.006) and might be associated with the lower CRC risk (OR: 0.78; 95% CI: 0.65-0.93). The relationship of rs12412320 with lower CRC risk was found in people aged >60 years and ≤60 years, women, non-smokers, or non-drinkers. Rs11245008 in people aged ≤60 years and rs11245007 among men had a higher CRC susceptibility. Rs12412320 was related to the lower risk of advanced stages (III/IV stage), while rs11245007 might be associated with the higher risk of advanced stages (III/IV stage). Moreover, rs12412320 had the most significant relationship with the susceptibility to rectal cancer.
UNASSIGNED: This study is the first to report between C10orf90 gene polymorphisms and CRC risk in Chinese people, which suggests that C10orf90 rs12412320 might play a crucial role in preventing CRC occurrence.
摘要：
■结直肠癌（CRC）是世界上第三大最常见的恶性肿瘤。西方国家的发病率和死亡率都有所下降,但他们仍在中国崛起。C10orf90与多种癌症有关，但C10orf90与CRC之间的相关性尚不清楚。
■共有1,339名受试者被随机纳入本研究。在提取了他们的DNA之后,对C10orf90的三个单核苷酸多态性(SNPs)进行基因分型,以分析这些变异与CRC风险之间的潜在关系.PLINK软件包（1.07版）通过计算比值比（OR）和95％置信区间（95％CI）来评估多个遗传模型。通过多因素降维（MDR）分析定义了最佳的SNP-SNP相互作用模型。
■C10orf90rs1212320与CRC风险显着相关（p=0.006），并且可能与较低的CRC风险相关（OR：0.78；95％CI：0.65-0.93）。rs12412320与较低CRC风险的关系在年龄>60岁和≤60岁的人群中发现。女人,非吸烟者,或者不喝酒的人。≤60岁人群的rs11245008和男性的rs11245007具有较高的CRC易感性。Rs12412320与晚期（III/IV期）的风险较低有关，而rs11245007可能与晚期（III/IV期）的高风险相关。此外，rs12412320与直肠癌的易感性关系最显著。
■本研究首次报道了C10orf90基因多态性与中国人CRC风险之间的关系，这表明C10orf90rs1212320可能在预防CRC发生中起关键作用。
■共有1,339名受试者被随机纳入本研究。在提取了他们的DNA之后,对C10orf90的三个单核苷酸多态性(SNPs)进行基因分型,以分析这些变异与CRC风险之间的潜在关系.PLINK软件包（1.07版）通过计算比值比（OR）和95％置信区间（95％CI）来评估多个遗传模型。通过多因素降维（MDR）分析定义了最佳的SNP-SNP相互作用模型。
■C10orf90rs1212320与CRC风险显着相关（p=0.006），并且可能与较低的CRC风险相关（OR：0.78；95％CI：0.65-0.93）。rs12412320与较低CRC风险的关系在年龄>60岁和≤60岁的人群中发现。女人,非吸烟者,或者不喝酒的人。≤60岁人群的rs11245008和男性的rs11245007具有较高的CRC易感性。Rs12412320与晚期（III/IV期）的风险较低有关，而rs11245007可能与晚期（III/IV期）的高风险相关。此外，rs12412320与直肠癌的易感性关系最显著。
■本研究首次报道了C10orf90基因多态性与中国人CRC风险之间的关系，这表明C10orf90rs1212320可能在预防CRC发生中起关键作用。
