PDF(Pubmed)
Abstract：
Background: Dry eye disease (DED) is a complex ocular surface inflammatory disorder with a multifactorial etiology. Therapies such as intense pulsed light (IPL) and heated eye mask (HEM) have been reported to improve the tear film lipid layer (TFLL) and signs and symptoms of DED. Methods: This randomized study aimed to compare the effects of IPL combined with HEM (IPL+HEM) group, IPL group, and control group in participants with evaporative DED. All participants were examined at baseline (D0), day 21 (D21), day 42 (D42), and day 84 (D84) for noninvasive tear breakup time (NITBUT), TFLL, corneal conjunctival staining (CS), meibomian gland quality (MGQ), meibomian gland expressibility (MGEx), and Ocular Surface Disease Index (OSDI). Results: The mean age of participants was IPL+HEM: 28.06 ± 3.88 years, IPL: 29.88 ± 4.68 years, and control: 28.52 ± 3.77 years. At D84, significant improvements in TFLL (p < 0.05), noninvasive tear breakup time (NITBUT) (p < 0.05), corneoconjunctival staining (CS) (p < 0.05), MGQ (p < 0.05), MGEx (p < 0.05), and OSDI (p < 0.05) were found in the IPL+HEM and IPL groups, whereas the control group had no significant improvements. Furthermore, ΔTFLL significantly correlated with ΔNITBUT (r = -0.678, p < 0.001), ΔCS (r = 0.321, p < 0.001), ΔMGQ (r = 0.669, p < 0.001), ΔMGEx (r = 0.598, p < 0.001), and ΔOSDI score (r = 0.649, p < 0.001). Conclusions: IPL therapy in combination with HEM and IPL therapy only can significantly improve the quality of TFLL and clinically reduce the sign and symptoms of evaporative DED. However, IPL therapy in combination with HEM was found to be more effective than IPL therapy alone.
摘要：
背景：干眼症（DED）是一种复杂的眼表炎症性疾病，具有多因素的病因。已经报道了诸如强脉冲光(IPL)和加热眼罩(HEM)的疗法改善泪膜脂质层(TFLL)和DED的体征和症状。方法:本随机研究旨在比较IPL联合HEM(IPL+HEM)组的疗效,IPL组,对照组为蒸发DED参与者。所有参与者在基线(D0)检查，第21天（D21），第42天（D42），第84天（D84）为非侵入性泪液破裂时间（NITBUT），TFLL,角膜结膜染色（CS），睑板腺质量（MGQ），睑板腺可表达性（MGEX），和眼表疾病指数（OSDI）。结果：参与者的平均年龄为IPL+HEM：28.06±3.88岁，IPL：29.88±4.68岁，和控制：28.52±3.77岁。在D84时，TFLL显着改善（p<0.05），无创性泪液破裂时间（NITBUT）（p<0.05），新结膜染色（CS）（p<0.05），MGQ（p<0.05），MGEX（p<0.05），在IPL+HEM和IPL组中发现OSDI（p<0.05），而对照组无显著改善。此外，ΔTFLL与ΔNITBUT显著相关(r=-0.678，p<0.001)，ΔCS（r=0.321，p<0.001），ΔMGQ（r=0.669，p<0.001），ΔMGex（r=0.598，p<0.001），和ΔOSDI评分(r=0.649,p<0.001)。结论：IPL治疗联合HEM和IPL治疗只能显着提高TFLL的质量，并在临床上减轻蒸发性DED的体征和症状。然而,发现与HEM组合的IPL疗法比单独的IPL疗法更有效。
