Abstract：
The Corynebacterium diphtheriae species complex comprises seven bacterial species, including Corynebacterium ulcerans, a zoonotic pathogen from multiple animal species. In this work, we characterise phenotypically and genotypically isolates belonging to two C. ulcerans lineages. Results from phylogenetic analyses, in silico DNA-DNA hybridization (DDH) and MALDI-TOF spectra differentiate lineage 2 from C. ulcerans lineage 1, which, together with their distinct transmission dynamics (probable human-to-human vs animal-to-human), indicates that lineage 2 is a separate Corynebacterium species, which we propose to name Corynebacterium ramonii. This species is of particular medical interest considering that its human-to-human transmission is likely, and that some C. ramonii isolates carry the diphtheria toxin gene.
摘要：
白喉棒杆菌物种复合物包含七个细菌物种，包括溃疡棒状杆菌,来自多种动物物种的人畜共患病原体。在这项工作中,我们从表型和基因型上鉴定了属于两个溃疡梭菌谱系的分离株。系统发育分析的结果，在硅DNA-DNA杂交（DDH）和MALDI-TOF光谱区分谱系2从C.ulcerans谱系1，以及它们独特的传播动力学（人对人与动物对人），表明谱系2是一个单独的棒杆菌属物种，我们建议将其命名为雷蒙氏棒杆菌。考虑到它很可能在人与人之间传播，这个物种特别有医学意义，一些雷蒙氏梭菌分离物携带白喉毒素基因。
