PDF(Pubmed)
Abstract：
A positive association between insulin resistance and osteoporosis has been widely established. However, crosstalk between the signalling molecules in insulin and Wingless (Wnt)/beta-(β-)catenin transduction cascades orchestrating bone homeostasis remains not well understood. The current review aims to collate the existing evidence, reporting (a) the expression of insulin signalling molecules involved in bone-related disorders and (b) the expression of Wnt/β-catenin signalling molecules involved in governing insulin homeostasis. The downstream effector molecule, glycogen synthase kinase-3 beta (GSK3β), has been identified to be a point of convergence linking the two signal transduction networks. This review highlights that GSK3β may be a drug target in the development of novel anabolic agents and the potential use of GSK3β inhibitors to treat bone-related disorders.
摘要：
胰岛素抵抗和骨质疏松症之间的正相关已被广泛确定。然而,胰岛素中的信号分子与无翼（Wnt）/β-（β-）连环蛋白转导级联协调骨稳态之间的串扰仍未得到很好的理解。本次检讨旨在整理现有证据,报告（a）参与骨相关疾病的胰岛素信号分子的表达和（b）参与控制胰岛素稳态的Wnt/β-catenin信号分子的表达。下游效应分子，糖原合成酶激酶-3β（GSK3β），已被确定为连接两个信号转导网络的汇合点。这篇综述强调了GSK3β可能是新型合成代谢药物开发的药物靶标，以及GSK3β抑制剂治疗骨相关疾病的潜在用途。
