PDF(Pubmed)
Abstract：
Sinonasal squamous cell carcinoma (SNSCC) and sinonasal undifferentiated carcinoma (SNUC) are two of the most common, high-grade malignancies of the sinonasal cavity. The standard of care for resectable lesions per the National Comprehensive Cancer Network (NCCN) guidelines includes surgical resection with negative margins plus adjuvant radiation therapy. However, surgery for locally advanced disease with both orbital and intracranial involvement is associated with significant morbidity and poor overall survival. Over the last decade, induction chemotherapy (IC) has emerged as part of a multimodal treatment strategy to optimize locoregional disease control and minimize substantial surgical morbidity such as orbital exenteration without compromising rates of overall survival. The response to IC both guides additional therapy and helps prognosticate a patient\'s disease. This narrative review examines the data surrounding the management of patients with SNSCC and SNUC. The pros and cons of upfront surgical management plus adjuvant therapy will be explored, and the case for IC will be presented. The IC-specific regimens and treatment paradigms for SNSCC and SNUC will each be explored in detail. Organ preservation, treatment morbidity, and survival data will be presented, and evidence-based recommendations will be presented for the management of these patients.
摘要：
鼻窦鳞状细胞癌(SNSCC)和鼻窦未分化癌(SNUC)是两种最常见的,鼻腔高级别恶性肿瘤。根据国家综合癌症网络（NCCN）指南，可切除病变的护理标准包括切缘阴性的手术切除加辅助放射治疗。然而,手术治疗眼眶和颅内受累的局部晚期疾病与显著的发病率和较低的总生存率相关.在过去的十年里，诱导化疗(IC)已作为多模式治疗策略的一部分出现,以优化局部疾病控制,并在不影响总生存率的情况下最大限度地减少大量手术发病率,例如眼眶切除术.对IC的反应既指导额外的治疗，也有助于预测患者的疾病。本叙述性综述检查了有关SNSCC和SNUC患者管理的数据。将探讨前期手术管理加辅助治疗的利弊，将介绍IC的情况。将详细探讨SNSCC和SNUC的IC特定方案和治疗范例。器官保存,治疗发病率，和生存数据将被提供，并将针对这些患者的管理提出基于证据的建议。
