Abstract：
OBJECTIVE: Understanding the global patterns of respiratory syncytial virus (RSV) is crucial for developing effective prevention and control strategies.
METHODS: Data on RSV-related burden were extracted from the Global Burden of Disease 2019. Joinpoint regression models were used to assess the global temporal trends of RSV and further stratified analyses were conducted according to the Socio-demographic Index (SDI), which is a composite measure of income, education, and total fertility. Age-period-cohort model was used to evaluate age, period, and cohort effects.
RESULTS: In 2019, the global age-standardized rate of mortality (ASMR) and disability-adjusted life years (ASR-DALYs) of RSV were 4.79/100,000 (95% uncertainty interval [95% UI]: 1.82/100,000-9.32/100,000) and 218.34/100,000 (95% UI: 92.06/100,000-376.80/100,000), respectively. The burden of RSV was higher in men than women. The highest ASMR (10.26/100,000, 3.80/100,000-20.16/100,000) and ASR-DALYs (478.71/100,000, 202.40/100,000-840.85/100,000) were reported in low-SDI region. Although mortality and DALYs rates in all age groups declined globally, the pace of decline was not uniform across age groups. Mortality rate in the elderly over 70 years surpassed that in children under 5 years in 2019.
CONCLUSIONS: This study highlights the need for targeted interventions to reduce the burden of RSV, particularly in low-SDI region, and among the elderly over 70 years.
METHODS: Data on RSV-related burden were extracted from the Global Burden of Disease 2019. Joinpoint regression models were used to assess the global temporal trends of RSV and further stratified analyses were conducted according to the Socio-demographic Index (SDI), which is a composite measure of income, education, and total fertility. Age-period-cohort model was used to evaluate age, period, and cohort effects.
RESULTS: In 2019, the global age-standardized rate of mortality (ASMR) and disability-adjusted life years (ASR-DALYs) of RSV were 4.79/100,000 (95% uncertainty interval [95% UI]: 1.82/100,000-9.32/100,000) and 218.34/100,000 (95% UI: 92.06/100,000-376.80/100,000), respectively. The burden of RSV was higher in men than women. The highest ASMR (10.26/100,000, 3.80/100,000-20.16/100,000) and ASR-DALYs (478.71/100,000, 202.40/100,000-840.85/100,000) were reported in low-SDI region. Although mortality and DALYs rates in all age groups declined globally, the pace of decline was not uniform across age groups. Mortality rate in the elderly over 70 years surpassed that in children under 5 years in 2019.
CONCLUSIONS: This study highlights the need for targeted interventions to reduce the burden of RSV, particularly in low-SDI region, and among the elderly over 70 years.
摘要：
目的：了解呼吸道合胞病毒（RSV）的全球模式对于制定有效的预防和控制策略至关重要。
方法：RSV相关负担数据来自2019年全球疾病负担。使用Joinpoint回归模型评估RSV的全球时间趋势，并根据社会人口统计学指数（SDI）进行进一步的分层分析。这是收入的综合衡量标准，教育,和总生育率。年龄-时期-队列模型用于评估年龄，period,和队列效应。
结果：2019年，RSV的全球年龄标准化死亡率（ASMR）和残疾调整寿命年（ASR-DALYs）分别为4.79/100,000（95％不确定区间[95％UI]：1.82/100,000-9.32/100,000）和218.34/100,000（95％UI：92.06/100,000-376.80/100分别。男性的RSV负担高于女性。在低SDI地区报告了最高的ASMR（10.26/100,000，3.80/100,000-20.16/100,000）和ASR-DALYs（478.71/100,000，202.40/100,000-840.85/100,000）。尽管全球所有年龄组的死亡率和DALY率都有所下降，各年龄组的下降速度并不一致.2019年，70岁以上老年人的死亡率超过5岁以下儿童的死亡率。
结论：本研究强调需要有针对性的干预措施来减轻RSV的负担。特别是在低SDI地区，70岁以上的老年人。
方法：RSV相关负担数据来自2019年全球疾病负担。使用Joinpoint回归模型评估RSV的全球时间趋势，并根据社会人口统计学指数（SDI）进行进一步的分层分析。这是收入的综合衡量标准，教育,和总生育率。年龄-时期-队列模型用于评估年龄，period,和队列效应。
结果：2019年，RSV的全球年龄标准化死亡率（ASMR）和残疾调整寿命年（ASR-DALYs）分别为4.79/100,000（95％不确定区间[95％UI]：1.82/100,000-9.32/100,000）和218.34/100,000（95％UI：92.06/100,000-376.80/100分别。男性的RSV负担高于女性。在低SDI地区报告了最高的ASMR（10.26/100,000，3.80/100,000-20.16/100,000）和ASR-DALYs（478.71/100,000，202.40/100,000-840.85/100,000）。尽管全球所有年龄组的死亡率和DALY率都有所下降，各年龄组的下降速度并不一致.2019年，70岁以上老年人的死亡率超过5岁以下儿童的死亡率。
结论：本研究强调需要有针对性的干预措施来减轻RSV的负担。特别是在低SDI地区，70岁以上的老年人。
