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Abstract：
Platelet mass index (PMI) as a prognostic indicator in pediatric sepsis has not been previously reported. In this retrospective observational study, we evaluated PMI\'s performance as a prognostic indicator in children aged younger than 18 years with sepsis and septic shock in relationship with survival. Over 5 years, we collected data from 122 children admitted to our pediatric intensive care unit (PICU). PMI accuracy was assessed with sensitivity and specificity and its discrimination was assessed using the area under the receiver operating characteristic curve (AUC). Median PMI values on days 1 and 3 of PICU admission were lower among nonsurvivors. On day 1 of PICU admission, a cutoff PMI value of 1,450 fL/nL resulted in a sensitivity of 72% and a specificity of 69%, and the AUC was 0.70 (95% confidence interval [CI]: 0.55-0.86). Similarly, on day 3, a cutoff of 900 fL/nL resulted in a sensitivity of 71% and a specificity of 70%, and the AUC was 0.76 (95% CI: 0.59-0.92). Our exploratory study suggests that low PMI in children with septic shock is associated with increased mortality. Considering the PMI\'s fair performance, further studies should be performed to assess its clinical value.
摘要：
血小板质量指数（PMI）作为小儿败血症的预后指标尚未见报道。在这项回顾性观察研究中，我们评估了PMI作为18岁以下脓毒症和脓毒性休克患儿预后指标的表现与生存率的关系.超过5年,我们收集了儿科重症监护病房(PICU)收治的122名儿童的数据.用敏感性和特异性评估PMI准确性，并使用受试者工作特征曲线下面积（AUC）评估其区别。非幸存者PICU入院第1天和第3天的PMI中位数较低。在PICU入院的第一天，截止PMI值为1,450fL/nL，灵敏度为72%，特异性为69%，AUC为0.70（95%置信区间[CI]：0.55-0.86）。同样，在第3天，900fL/nL的截止值导致71％的灵敏度和70％的特异性，AUC为0.76（95%CI：0.59-0.92）。我们的探索性研究表明，感染性休克患儿的低PMI与死亡率增加有关。考虑到PMI的公平表现，应进行进一步研究以评估其临床价值.
