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Abstract：
Myelofibrosis is a myeloproliferative tumor, that can be secondary to malignant hematologic or inflammatory diseases, such as chronic myeloid leukemia, polycythemia vera, primary thrombocythemia, multiple myeloma, disseminated tuberculosis, or vasculitis. However, few cases of brucellosis-associated myelofibrosis have been reported. Moreover, due to the rarity of this phenomenon, it is often overlooked by clinicians, resulting in misdiagnosis and mismanagement. Thus, brucellosis should be considered as a possible cause of myelofibrosis. In the present study, we report five cases of brucellosis, of which three had myelofibrosis. In addition, to further determine the potential link between brucellosis and myelofibrosis, we retrospectively analyzed the levels of various cytokines by collecting the clinicopathologic data of patients and using immunohistochemical staining. We found that brucellosis patients with myelofibrosis had elevated levels of cytokines such as interferon (IFN)-γ, interleukin (IL)-1β, basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), suggesting that the regulation of cytokines may play a central role in the development of myelofibrosis in patients with brucellosis.
摘要：
骨髓纤维化是一种骨髓增生性肿瘤，可能继发于恶性血液病或炎性疾病，比如慢性粒细胞白血病，真性红细胞增多症,原发性血小板增多症,多发性骨髓瘤,播散性结核病，或者血管炎.然而,很少有布鲁氏菌病相关骨髓纤维化的报道。此外，由于这种现象的罕见，它经常被临床医生忽视，导致误诊和管理不善。因此，布鲁氏菌病应被认为是骨髓纤维化的可能原因。在本研究中,我们报告了5例布鲁氏菌病，其中三人患有骨髓纤维化。此外,为了进一步确定布鲁氏菌病和骨髓纤维化之间的潜在联系，我们通过收集患者的临床病理资料并使用免疫组织化学染色对各种细胞因子水平进行回顾性分析。我们发现布鲁氏菌病伴骨髓纤维化患者的细胞因子水平升高，如干扰素（IFN）-γ，白细胞介素（IL）-1β，碱性成纤维细胞生长因子（b-FGF），血管内皮生长因子（VEGF），提示细胞因子的调节可能在布鲁氏菌病患者骨髓纤维化的发展中起重要作用。
