Abstract：
Iron overload increases the production of harmful reactive oxygen species in the Fenton reaction, which causes oxidative stress in the body and lipid peroxidation in the cell membrane, and eventually leads to ferroptosis. Diabetes is associated with increased intracellular oxidative stress, inflammation, autophagy, microRNA alterations, and advanced glycation end products (AGEs), which cause cardiac remodeling and cardiac diastolic contractile dysfunction, leading to the development of diabetic cardiomyopathy (DCM). While these factors are also closely associated with ferroptosis, more and more studies have shown that iron-mediated ferroptosis is an important causative factor in DCM. In order to gain fresh insights into the functions of ferroptosis in DCM, this review methodically summarizes the traits and mechanisms connected with ferroptosis and DCM.
摘要：
铁过载会增加Fenton反应中有害活性氧的产生，导致体内的氧化应激和细胞膜的脂质过氧化，并最终导致铁中毒。糖尿病与细胞内氧化应激增加有关，炎症,自噬,microRNA改变,和晚期糖基化终产物(AGEs)，导致心脏重塑和心脏舒张收缩功能障碍，导致糖尿病心肌病（DCM）的发展。虽然这些因素也与铁死亡密切相关，越来越多的研究表明铁介导的铁死亡是DCM的重要致病因素。为了获得对DCM中铁凋亡功能的新见解，这篇综述系统地总结了与铁凋亡和DCM相关的特征和机制。
