Abstract：
For a considerable duration, cervical cancer has posed a significant risk to the well-being and survival of women. The emergence and progression of cervical cancer have garnered extensive attention, with prolonged chronic infection of HPV serving as a crucial etiological factor. Consequently, investigating the molecular mechanism underlying HPV-induced cervical cancer has become a prominent research area. The HPV molecule is composed of a long control region (LCR), an early coding region and a late coding region.The early coding region encompasses E1, E2, E4, E5, E6, E7, while the late coding region comprises L1 and L2 ORF.The investigation into the molecular structure and function of HPV has garnered significant attention, with the aim of elucidating the carcinogenic mechanism of HPV and identifying potential targets for the treatment of cervical cancer. Research has demonstrated that the HPV gene and its encoded protein play a crucial role in the invasion and malignant transformation of host cells. Consequently, understanding the function of HPV oncoprotein is of paramount importance in comprehending the pathogenesis of cervical cancer. E6 and E7, the primary HPV oncogenic proteins, have been the subject of extensive study. Moreover, a number of contemporary investigations have demonstrated the significant involvement of HPV16 E5 oncoprotein in the malignant conversion of healthy cells through its regulation of cell proliferation, differentiation, and apoptosis via diverse pathways, albeit the precise molecular mechanism remains unclear. This manuscript aims to provide a comprehensive account of the molecular structure and life cycle of HPV.The HPV E5 oncoprotein mechanism modulates cellular processes such as proliferation, differentiation, apoptosis, and energy metabolism through its interaction with cell growth factor receptors and other cellular proteins. This mechanism is crucial for the survival, adhesion, migration, and invasion of tumor cells in the early stages of carcinogenesis. Recent studies have identified the HPV E5 oncoprotein as a promising therapeutic target for early-stage cervical cancer, thus offering a novel approach for treatment.
摘要：
在相当长的时间里，宫颈癌对妇女的健康和生存构成了重大风险。宫颈癌的发生和进展引起了广泛的关注,HPV的长期慢性感染是一个关键的病因。因此,研究HPV诱导宫颈癌的分子机制已成为一个重要的研究领域。HPV分子由长控制区（LCR）组成，早期编码区和晚期编码区。早期编码区包括E1、E2、E4、E5、E6、E7,而晚期编码区包括L1和L2ORF。HPV的分子结构和功能的研究引起了人们的极大关注,目的是阐明HPV的致癌机制并确定治疗宫颈癌的潜在靶标。研究表明，HPV基因及其编码蛋白在宿主细胞的侵袭和恶性转化中起着至关重要的作用。因此,了解HPV癌蛋白的功能对于理解宫颈癌的发病机制至关重要。E6和E7，主要的HPV致癌蛋白，一直是广泛研究的主题。此外，许多当代研究表明，HPV16E5癌蛋白通过调节细胞增殖而显著参与健康细胞的恶性转化，分化,和通过不同途径的细胞凋亡，尽管确切的分子机制尚不清楚。本手稿旨在全面介绍HPV的分子结构和生命周期。HPVE5癌蛋白机制调节细胞过程，如增殖，分化,凋亡，和能量代谢通过其与细胞生长因子受体和其他细胞蛋白质的相互作用。这种机制对生存至关重要，附着力,迁移,和肿瘤细胞在癌变早期的侵袭。最近的研究已经确定HPVE5癌蛋白是早期宫颈癌的一个有希望的治疗靶点。从而提供了一种新的治疗方法。
