Abstract：
OBJECTIVE: This study aimed to compare osseointegration and osteogenesis after single-stage maxillary sinus augmentation with the lateral window using particulate deproteinized porcine bone mineral (PDPBM) and collagenated block deproteinized porcine bone mineral (BDPBM).
METHODS: Bi-maxillary premolars of six beagle dogs were extracted. Eight weeks later, an implant was placed into each augmented sinus with PDPBM or BDPBM according to a split-mouth design. Eight weeks later, all specimens were harvested. Each specimen was separated into the region of interest with the implant (ROI-I) and region of interest with sinus augmented area (ROI-S) 5 mm away from ROI-I. ROI-I and ROI-S were evaluated through micro-computed tomography and histomorphometry.
RESULTS: Bone substitute insertion took longer for the PDPBM group than for the BDPBM group (P = 0.002). In ROI-I, three-dimensional bone-to-implant contact (BIC) did not show statistically significant differences between the groups. Two-dimensional BIC also showed comparable values for both groups. In ROI-S, the graft material volume/tissue volume, trabecular bone pattern factor, and structural model index were higher in the BDPBM group than in the PDPBM group (P < 0.05). The proportions of new bone, graft material, and connective tissue were not significantly statistically different between groups. Less new bone was found in the apical area than in the coronal or middle areas in the BCPBM group (P < 0.05).
CONCLUSIONS: BDPBM may save time in inserting bone substitutes and provide comparable osteogenesis and osseointegration to PDPBM.
CONCLUSIONS: When performing sinus augmentation, BDPBM might improve operator\'s convenience with comparable biological results compared to PDPBM.
METHODS: Bi-maxillary premolars of six beagle dogs were extracted. Eight weeks later, an implant was placed into each augmented sinus with PDPBM or BDPBM according to a split-mouth design. Eight weeks later, all specimens were harvested. Each specimen was separated into the region of interest with the implant (ROI-I) and region of interest with sinus augmented area (ROI-S) 5 mm away from ROI-I. ROI-I and ROI-S were evaluated through micro-computed tomography and histomorphometry.
RESULTS: Bone substitute insertion took longer for the PDPBM group than for the BDPBM group (P = 0.002). In ROI-I, three-dimensional bone-to-implant contact (BIC) did not show statistically significant differences between the groups. Two-dimensional BIC also showed comparable values for both groups. In ROI-S, the graft material volume/tissue volume, trabecular bone pattern factor, and structural model index were higher in the BDPBM group than in the PDPBM group (P < 0.05). The proportions of new bone, graft material, and connective tissue were not significantly statistically different between groups. Less new bone was found in the apical area than in the coronal or middle areas in the BCPBM group (P < 0.05).
CONCLUSIONS: BDPBM may save time in inserting bone substitutes and provide comparable osteogenesis and osseointegration to PDPBM.
CONCLUSIONS: When performing sinus augmentation, BDPBM might improve operator\'s convenience with comparable biological results compared to PDPBM.
摘要：
目的：本研究旨在比较使用颗粒脱蛋白猪骨矿物质（PDPBM）和胶原块脱蛋白猪骨矿物质（BDPBM）进行单阶段上颌窦增强后的骨整合和成骨作用。
方法：提取6只比格犬的上颌双前磨牙。八周后,根据裂口设计,用PDPBM或BDPBM将植入物置入每个扩张窦内.八周后,所有标本均已收获。将每个样本分离为具有植入物的感兴趣区域（ROI-I）和具有距ROI-I5mm的窦性增强区域（ROI-S）的感兴趣区域。通过显微计算机断层扫描和组织形态计量学评估ROI-I和ROI-S。
结果：PDPBM组的骨替代物插入时间长于BDPBM组（P=0.002）。在ROI-I中，三维骨-种植体接触(BIC)在组间没有统计学显著差异.两组的二维BIC也显示出相当的值。在ROI-S中，移植材料体积/组织体积，骨小梁模式因子，BDPBM组的结构模型指数高于PDPBM组(P<0.05)。新骨的比例，移植材料,两组间结缔组织差异无统计学意义。BCPBM组根尖区新骨较冠状区或中部区少(P<0.05)。
结论：BDPBM可以节省插入骨替代物的时间，并提供与PDPBM相当的骨生成和骨整合。
结论：当进行鼻窦扩张时，与PDPBM相比，BDPBM可以通过可比的生物学结果提高操作员的便利性。
方法：提取6只比格犬的上颌双前磨牙。八周后,根据裂口设计,用PDPBM或BDPBM将植入物置入每个扩张窦内.八周后,所有标本均已收获。将每个样本分离为具有植入物的感兴趣区域（ROI-I）和具有距ROI-I5mm的窦性增强区域（ROI-S）的感兴趣区域。通过显微计算机断层扫描和组织形态计量学评估ROI-I和ROI-S。
结果：PDPBM组的骨替代物插入时间长于BDPBM组（P=0.002）。在ROI-I中，三维骨-种植体接触(BIC)在组间没有统计学显著差异.两组的二维BIC也显示出相当的值。在ROI-S中，移植材料体积/组织体积，骨小梁模式因子，BDPBM组的结构模型指数高于PDPBM组(P<0.05)。新骨的比例，移植材料,两组间结缔组织差异无统计学意义。BCPBM组根尖区新骨较冠状区或中部区少(P<0.05)。
结论：BDPBM可以节省插入骨替代物的时间，并提供与PDPBM相当的骨生成和骨整合。
结论：当进行鼻窦扩张时，与PDPBM相比，BDPBM可以通过可比的生物学结果提高操作员的便利性。
