Abstract：
To investigate the association between phototherapy (PT) and the development of necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants.
A retrospective case-control study was conducted on VLBW infants with or without NEC (stage IIA or greater) born at ≤35 weeks\' gestation in a tertiary hospital over 7 years. Sample size calculation, trend test, as well as univariate and multiple logistic regression analyses were employed.
A total of 824 VLBW infants were reviewed, with 74 cases and 122 controls finally enrolled. The odds of NEC increased with the duration and number of PT sessions. Exposure to >120 h and >4 instances of PT were significantly associated with NEC in multivariate analysis.
This is the first study suggesting a potential association between PT and development of NEC in VLBW infants. This association needs further exploration.
A retrospective case-control study was conducted on VLBW infants with or without NEC (stage IIA or greater) born at ≤35 weeks\' gestation in a tertiary hospital over 7 years. Sample size calculation, trend test, as well as univariate and multiple logistic regression analyses were employed.
A total of 824 VLBW infants were reviewed, with 74 cases and 122 controls finally enrolled. The odds of NEC increased with the duration and number of PT sessions. Exposure to >120 h and >4 instances of PT were significantly associated with NEC in multivariate analysis.
This is the first study suggesting a potential association between PT and development of NEC in VLBW infants. This association needs further exploration.
摘要：
目的：探讨光疗（PT）与极低出生体重（VLBW）婴儿坏死性小肠结肠炎（NEC）发生的关系。
方法：对三级医院7年以上妊娠≤35周出生的有或没有NEC（IIA期或以上）的VLBW婴儿进行了回顾性病例对照研究。样本量计算,趋势测试，以及单变量和多元逻辑回归分析。
结果：共对824例VLBW婴儿进行了回顾，最终纳入74例病例和122例对照。NEC的几率随着PT会话的持续时间和数量而增加。在多变量分析中，暴露于>120小时和>4例PT与NEC显著相关。
结论：这是第一项研究表明PT与VLBW婴儿NEC发育之间存在潜在关联。这种联系需要进一步探索。
方法：对三级医院7年以上妊娠≤35周出生的有或没有NEC（IIA期或以上）的VLBW婴儿进行了回顾性病例对照研究。样本量计算,趋势测试，以及单变量和多元逻辑回归分析。
结果：共对824例VLBW婴儿进行了回顾，最终纳入74例病例和122例对照。NEC的几率随着PT会话的持续时间和数量而增加。在多变量分析中，暴露于>120小时和>4例PT与NEC显著相关。
结论：这是第一项研究表明PT与VLBW婴儿NEC发育之间存在潜在关联。这种联系需要进一步探索。
