PubMed, Embase, and the Cochrane Library were searched. Studies utilizing laboratory tests to assist in the diagnosis of NS were included. The pooled indicators for diagnostic performance and their respective 95% confidence intervals (CIs) were calculated. We used the superiority index to test the superiority of a diagnostic test.
Eleven citations were included in the study. Albumin quotient, CSF-TPHA, CSF-EIA, CSF-LDH, CSF-WBC, CSF-CXCL13, FTA-ABS, CSF-PCR, RPR, CSF-TPPA, TRUST, and CSF-venereal diseases research laboratory (VDRL) were assessed in the studies included. The pooled estimates of sensitivity, specificity, AUC of SROC and their respective 95% CIs for CSF-TPPA and CSF-VDRL were 0.97 (0.17, 1.00), 0.84 (0.62, 0.95), 0.93 (0.91, 0.95) and 0.74 (0.59, 0.85), 0.99 (0.93, 1.00), 0.94 (0.91, 0.96), respectively. CSF-TPHA demonstrated the highest relative sensitivity. CSF-VDRL manifested the highest specificity. CSF-TPHA, TRUST, CSF-VDRL, CSF-EIA, and RPR ranked in the top five laboratory tests with superiority index.
CSF-TPHA, TRUST, CSF-VDRL, CSF-EIA, and RPR indicate acceptable performance in detecting NS compared to other modalities. Comprehensive diagnostic strategies still play a significant role in the diagnosis of NS.
方法:PubMed,Embase,搜索了Cochrane图书馆.包括利用实验室测试来辅助NS诊断的研究。计算诊断性能的汇总指标及其各自的95%置信区间(CI)。我们使用优势指数来测试诊断测试的优越性。
结果:研究中包括11篇引文。白蛋白商,CSF-TPHA,CSF-EIA,CSF-LDH,CSF-WBC,CSF-CXCL13,FTA-ABS,CSF-PCR,RPR,CSF-TPPA,信任,和CSF-VDRL在纳入的研究中进行评估。敏感性的汇总估计,特异性,CSF-TPPA和CSF-VDRL的SROC及其各自的95%CI为0.97(0.17,1.00),0.84(0.62,0.95),0.93(0.91,0.95)和0.74(0.59,0.85),0.99(0.93,1.00),0.94(0.91,0.96),分别。CSF-TPHA表现出最高的相对灵敏度。CSF-VDRL表现出最高的特异性。CSF-TPHA,信任,CSF-VDRL,CSF-EIA,RPR以优势指数排名前五。
结论:CSF-TPHA,信任,CSF-VDRL,CSF-EIA,与其他模式相比,RPR和RPR表明检测NS的性能可接受。综合诊断策略在NS的诊断中仍然发挥着重要作用。