PDF(Pubmed)
Abstract：
Neonicotinoid pesticides (NNs) transfer rapidly from mother to offspring, which exhibit neurobehavioral effects. However, no studies have investigated NNs\' transgenerational effects. We exposed F0 generation mice (mothers) to a no-observed-adverse-effect level (NOAEL) of clothianidin (CLO) during gestation and lactation, and examined the adult neurobehavioral effects of three generations of offspring (F1, F2, F3). F1 had lower birth weight, decreased locomotor activity, and increased anxiety-like behavior. In F2, body weight was affected, and there was a decreasing trend in locomotor activity and an increasing trend in anxiety-like behavior. In F3, locomotor activity tended to increase. Thus, even when only the mothers were exposed, the effects of CLOs were still observed in F1, F2, and F3 but the effects became smaller.
摘要：
新烟碱类杀虫剂（NNs）迅速从母亲转移到后代，表现出神经行为效应。然而,没有研究调查神经网络的跨代效应。我们在妊娠和哺乳期将F0代小鼠（母亲）暴露于未观察到的副作用水平（NOAEL）的噻虫胺（CLO），并检查了三代后代（F1，F2，F3）的成年神经行为效应。F1出生体重较低，运动活动减少，并增加了焦虑样的行为。在F2中，体重受到影响，运动活动呈下降趋势，焦虑样行为呈上升趋势。在F3中,运动活性趋于增加。因此，即使只有母亲被曝光，在F1、F2和F3中仍观察到CLO的影响，但影响变小。
