METHODS: This case-control study was performed on 135 CRC cases and 294 healthy controls in Tehran, Iran. Data on demographic factors, anthropometric measurements, physical activity, the intake of different types of dietary fats, and FTO gene rs9939609 polymorphism was collected from all participants. The association between cancer and dietary fat intake in individuals with different FTO genotypes was assessed using different models of logistic regression.
RESULTS: Oleic acid intake was higher in the case group compared to the control group in both people with TT (7.2±3.46 vs. 5.83±3.06 g/d, P=0.02) and AA/AT genotypes (8.7±6.23 vs. 5.57 ±3.2 g/d, P<0.001). Among carriers of AA/AT genotypes of FTO rs9939609 polymorphism, a positive association was found between CRC and higher intakes of oleic acid (OR=1.12, CI95% 1.03-1.21, P=0.01) and cholesterol (OR=1.01, CI95% 1.00-1.02; P=0.01) after adjusting for age, sex, physical activity, alcohol use, smoking, calorie intake, and body mass index.
CONCLUSIONS: Higher intakes of cholesterol and oleic acid were associated with a higher risk of CRC in FTO-risk allele carriers. The association of CRC and dietary fat may be influenced by the FTO genotype. Further longitudinal studies are warranted to confirm these findings.
方法:这项病例对照研究是对德黑兰的135例CRC病例和294例健康对照进行的,伊朗。关于人口因素的数据,人体测量,身体活动,摄入不同类型的膳食脂肪,收集所有参与者的FTO基因rs9939609多态性。使用不同的逻辑回归模型评估具有不同FTO基因型的个体中癌症与膳食脂肪摄入之间的关联。
结果:两组TT患者的油酸摄入量均高于对照组(7.2±3.46vs.5.83±3.06g/d,P=0.02)和AA/AT基因型(8.7±6.23vs.5.57±3.2g/d,P<0.001)。在FTOrs9939609多态性的AA/AT基因型携带者中,在校正年龄后,CRC与油酸(OR=1.12,CI95%1.03-1.21,P=0.01)和胆固醇(OR=1.01,CI95%1.00-1.02;P=0.01)的较高摄入量之间呈正相关,性别,身体活动,酒精使用,吸烟,卡路里摄入量,和体重指数。
结论:较高的胆固醇和油酸摄入量与FTO风险等位基因携带者的CRC风险较高相关。CRC和膳食脂肪的关联可能受FTO基因型的影响。需要进一步的纵向研究来证实这些发现。