PDF(Pubmed)
Abstract：
UNASSIGNED: This study aims to analyze the distribution of human papillomavirus (HPV) genotypes and the associations of demographic characteristics with HPV infection among women with condyloma acuminatum (CA) in Henan Province of China.
UNASSIGNED: From January 2019 to October 2022, 702 women with CA were sampled for HPV subtypes and surveyed by questionnaire at Henan Provincial People\'s Hospital. The HPV genotype was tested by flow-through hybridization after polymerase chain reaction (PCR).
UNASSIGNED: The location of warts was mainly vulva. The age of the subjects was mainly distributed in the 20-29-year-old, followed by 30-39-year-old. The most common subtypes were HPV 6 (43.59%), 11 (24.93%), 16 (11.82%), 52 (7.83%), 58 (7.55%), 51 (7.26%), 61 (5.70%), 39 (5.56%), 18 (5.13%), and 54 (4.70%), our results also suggested that HPV 6 and 11 were the dominant genotypes in each age group. The infection of low-risk HPV (LR-HPV) (74.50%) and single HPV (47.01%) were the main categories. In terms of educational level, women with senior high school or above were inclined to infect single and pure-LR HPV. Unmarried status, sometimes or never condom use increased the chances of multiple, pure high-risk (HR) and mixed HPV infections. Women with multiple sex partners were more likely to cause multiple and mixed HPV infections.
UNASSIGNED: Our experimental data on the prevalence and subtype distribution of HPV in women with CA could provide valuable reference for preventing CA in Henan Province. The application of the nine-valent vaccine provides a broad prospect for female CA prevention.
UNASSIGNED: From January 2019 to October 2022, 702 women with CA were sampled for HPV subtypes and surveyed by questionnaire at Henan Provincial People\'s Hospital. The HPV genotype was tested by flow-through hybridization after polymerase chain reaction (PCR).
UNASSIGNED: The location of warts was mainly vulva. The age of the subjects was mainly distributed in the 20-29-year-old, followed by 30-39-year-old. The most common subtypes were HPV 6 (43.59%), 11 (24.93%), 16 (11.82%), 52 (7.83%), 58 (7.55%), 51 (7.26%), 61 (5.70%), 39 (5.56%), 18 (5.13%), and 54 (4.70%), our results also suggested that HPV 6 and 11 were the dominant genotypes in each age group. The infection of low-risk HPV (LR-HPV) (74.50%) and single HPV (47.01%) were the main categories. In terms of educational level, women with senior high school or above were inclined to infect single and pure-LR HPV. Unmarried status, sometimes or never condom use increased the chances of multiple, pure high-risk (HR) and mixed HPV infections. Women with multiple sex partners were more likely to cause multiple and mixed HPV infections.
UNASSIGNED: Our experimental data on the prevalence and subtype distribution of HPV in women with CA could provide valuable reference for preventing CA in Henan Province. The application of the nine-valent vaccine provides a broad prospect for female CA prevention.
摘要：
■本研究旨在分析中国河南省尖锐湿疣（CA）女性中人乳头瘤病毒（HPV）基因型的分布以及人口统计学特征与HPV感染的关系。
■自2019年1月至2022年10月，在河南省人民医院抽取702名女性CA患者的HPV亚型进行问卷调查。通过聚合酶链反应（PCR）后的流通杂交测试HPV基因型。
■疣的位置主要是外阴。受试者年龄主要分布在20-29岁,其次是30-39岁。最常见的亚型是HPV6（43.59％），11（24.93%），16（11.82%），52（7.83%），58（7.55%），51（7.26%），61（5.70%），39（5.56%），18（5.13%），和54（4.70％），我们的结果还提示HPV6和11是各年龄组的优势基因型.以低危型HPV(LR-HPV)(74.50%)和单一HPV(47.01%)感染为主。就教育水平而言,高中及以上女性倾向于感染单一和纯LR型HPV.未婚身份,有时或从不使用避孕套会增加多次使用的机会，纯高风险（HR）和混合HPV感染。有多个性伴侣的女性更有可能导致多重和混合HPV感染。
■我们对女性CA患者HPV的患病率和亚型分布的实验数据可为河南省预防CA提供有价值的参考。九价疫苗的应用为女性CA的预防提供了广阔的前景。
■自2019年1月至2022年10月，在河南省人民医院抽取702名女性CA患者的HPV亚型进行问卷调查。通过聚合酶链反应（PCR）后的流通杂交测试HPV基因型。
■疣的位置主要是外阴。受试者年龄主要分布在20-29岁,其次是30-39岁。最常见的亚型是HPV6（43.59％），11（24.93%），16（11.82%），52（7.83%），58（7.55%），51（7.26%），61（5.70%），39（5.56%），18（5.13%），和54（4.70％），我们的结果还提示HPV6和11是各年龄组的优势基因型.以低危型HPV(LR-HPV)(74.50%)和单一HPV(47.01%)感染为主。就教育水平而言,高中及以上女性倾向于感染单一和纯LR型HPV.未婚身份,有时或从不使用避孕套会增加多次使用的机会，纯高风险（HR）和混合HPV感染。有多个性伴侣的女性更有可能导致多重和混合HPV感染。
■我们对女性CA患者HPV的患病率和亚型分布的实验数据可为河南省预防CA提供有价值的参考。九价疫苗的应用为女性CA的预防提供了广阔的前景。
