PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies on the association between diet and breast cancer are mostly from Western populations, and data from Middle East countries are scarce, where the prevalence of breast cancer is high; therefore, it ranks first among other cancers. This population-based case-control study aimed to investigate the relationship between a Mediterranean-style diet and breast cancer among Iranian women.
UNASSIGNED: In the current study, 350 new cases of breast cancer and 700 age- and socioeconomic status-matched controls were enrolled. We evaluated the dietary intakes of participants by using a 106-item Willett-format semi-quantitative dish-based food frequency questionnaire (SQ-FFQ). We calculated the Mediterranean diet score according to the dietary intakes of participants. In addition, using pre-tested questionnaires, we collected information on potential confounding variables.
UNASSIGNED: In this study, we found a significant inverse association between the Mediterranean diet and breast cancer so that after controlling for potential confounders, individuals in the highest tertile of the Mediterranean diet score compared with those in the lowest tertile were 57% less likely to have breast cancer [odds ratio (OR): 0.43, 95% confidence interval (CI): 0.28-0.67]. Such an inverse association was also observed for postmenopausal women. Similarly, after controlling for potential confounding variables, high adherence to the Mediterranean dietary pattern was associated with lower odds of breast cancer (OR: 0.37, 95% CI: 0.23-0.60). However, this relationship was not significant among premenopausal women.
UNASSIGNED: We found that adherence to Mediterranean dietary pattern was associated with reduced odds of breast cancer. Studies with prospective design are needed to further examine this association.
UNASSIGNED: In the current study, 350 new cases of breast cancer and 700 age- and socioeconomic status-matched controls were enrolled. We evaluated the dietary intakes of participants by using a 106-item Willett-format semi-quantitative dish-based food frequency questionnaire (SQ-FFQ). We calculated the Mediterranean diet score according to the dietary intakes of participants. In addition, using pre-tested questionnaires, we collected information on potential confounding variables.
UNASSIGNED: In this study, we found a significant inverse association between the Mediterranean diet and breast cancer so that after controlling for potential confounders, individuals in the highest tertile of the Mediterranean diet score compared with those in the lowest tertile were 57% less likely to have breast cancer [odds ratio (OR): 0.43, 95% confidence interval (CI): 0.28-0.67]. Such an inverse association was also observed for postmenopausal women. Similarly, after controlling for potential confounding variables, high adherence to the Mediterranean dietary pattern was associated with lower odds of breast cancer (OR: 0.37, 95% CI: 0.23-0.60). However, this relationship was not significant among premenopausal women.
UNASSIGNED: We found that adherence to Mediterranean dietary pattern was associated with reduced odds of breast cancer. Studies with prospective design are needed to further examine this association.
摘要：
■以前关于饮食与乳腺癌之间关联的研究大多来自西方人群，中东国家的数据很少，乳腺癌的患病率很高；因此，它在其他癌症中排名第一。这项基于人群的病例对照研究旨在调查地中海式饮食与伊朗女性乳腺癌之间的关系。
■在当前的研究中，纳入了350例新的乳腺癌病例和700例年龄和社会经济状况匹配的对照。我们通过使用106项Willett格式的半定量基于菜肴的食物频率问卷（SQ-FFQ）评估了参与者的饮食摄入量。我们根据参与者的饮食摄入量计算地中海饮食得分。此外,使用预先测试的问卷，我们收集了有关潜在混杂变量的信息.
■在这项研究中，我们发现地中海饮食与乳腺癌之间存在显著的负相关，因此在控制了潜在的混杂因素后，地中海饮食得分最高三分位数的个体与最低三分位数的个体相比,患乳腺癌的可能性降低57%[比值比(OR):0.43,95%置信区间(CI):0.28~0.67].在绝经后妇女中也观察到了这种负相关。同样，在控制了潜在的混杂变量之后，高度坚持地中海饮食模式与乳腺癌发生几率较低相关(OR:0.37,95%CI:0.23~0.60).然而,这种关系在绝经前妇女中并不显著.
■我们发现坚持地中海饮食模式与降低患乳腺癌的几率有关。需要前瞻性设计的研究来进一步检查这种关联。
■在当前的研究中，纳入了350例新的乳腺癌病例和700例年龄和社会经济状况匹配的对照。我们通过使用106项Willett格式的半定量基于菜肴的食物频率问卷（SQ-FFQ）评估了参与者的饮食摄入量。我们根据参与者的饮食摄入量计算地中海饮食得分。此外,使用预先测试的问卷，我们收集了有关潜在混杂变量的信息.
■在这项研究中，我们发现地中海饮食与乳腺癌之间存在显著的负相关，因此在控制了潜在的混杂因素后，地中海饮食得分最高三分位数的个体与最低三分位数的个体相比,患乳腺癌的可能性降低57%[比值比(OR):0.43,95%置信区间(CI):0.28~0.67].在绝经后妇女中也观察到了这种负相关。同样，在控制了潜在的混杂变量之后，高度坚持地中海饮食模式与乳腺癌发生几率较低相关(OR:0.37,95%CI:0.23~0.60).然而,这种关系在绝经前妇女中并不显著.
■我们发现坚持地中海饮食模式与降低患乳腺癌的几率有关。需要前瞻性设计的研究来进一步检查这种关联。
