Abstract：
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited proliferative capacity on tumor cells, but is also involved in tumor progression and aggressiveness. In differentiated thyroid carcinoma, TERT-p mutations are associated with a number of high-risk clinicopathological aggressiveness and worse prognosis, making it the best molecular marker to predict tumor aggressiveness so far. This review summarizes recent relevant findings regarding TERT-p mutations and their functional/mechanistic aspects.
摘要：
TERT启动子突变（TERT-p突变）已在许多类型的癌症中发现，并已出现在肿瘤进展中起关键作用。突变上调TERT转录，TERT不仅延长端粒，并赋予肿瘤细胞无限的增殖能力，但也与肿瘤进展和侵袭性有关。在分化型甲状腺癌中，TERT-p突变与许多高风险的临床病理侵袭性和较差的预后相关。使其成为迄今为止预测肿瘤侵袭性的最佳分子标志物。这篇综述总结了有关TERT-p突变及其功能/机制方面的最新相关发现。
