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Abstract：
Post-surgery recurrence of meningiomas with multiple extracranial metastases is rare. Currently, information on extracranial metastases is limited, and no clear predictors and standardized treatment protocols can be applied clinically. Herein, we report a case of meningioma that recurred after two surgeries and had multiple distant metastases. Computed tomography revealed multiple enlarged lymph nodes in the para-aortic arch, left lower lung region, retroperitoneum, and abdominopelvic region, as well as soft tissue mass-like lesions under the liver capsule in the right lobe of the liver. Magnetic resonance imaging showed space-occupying lesions under the cranial plate of the left parietal lobe. Tissue biopsy confirmed the diagnosis of recurrent meningioma with extracranial metastases. Immune checkpoint inhibitors and anti-angiogenic drugs were administered. After two treatment cycles, the patient\'s clinical symptoms were significantly relieved, and the imaging assessment confirmed a stable disease. Although it did not meet our expectations, this combination therapy still demonstrated a possible benefit in improving meningioma patients\' survival and quality of life. In this report, along with the case, we also review the relevant literature on the subject and discuss the associated risk factors and treatment options.
摘要：
伴有多发性颅外转移的脑膜瘤的手术后复发很少见。目前,关于颅外转移的信息有限，没有明确的预测因素和标准化的治疗方案可以在临床上应用。在这里，我们报告了一例脑膜瘤，在两次手术后复发，并有多个远处转移。计算机断层扫描显示主动脉弓旁多个肿大的淋巴结，左下肺区,腹膜后,和腹骨盆区，以及肝右叶肝囊下软组织肿块样病变。磁共振成像显示左顶叶颅板下占位病变。组织活检证实诊断为复发性脑膜瘤伴颅外转移。施用免疫检查点抑制剂和抗血管生成药物。两个治疗周期后，患者的临床症状明显缓解,影像学评估证实病情稳定。虽然没有达到我们的期望,这种联合疗法在改善脑膜瘤患者的生存率和生活质量方面仍有可能获益.在这份报告中,随着案件，我们还回顾了相关文献,并讨论了相关的危险因素和治疗方案.
