PDF(Pubmed)
Abstract：
Background: The relationship between HLA-B*15:02 and Severe Cutaneous Adverse Reactions was rigorously examined in Japanese, Han Chinese, Thais, and Caucasians. However, the number of studies about this topic in Vietnamese population is still limited and mostly focuses on the North of Vietnam. Objective: This study aims to clarify the genetic culprit of SCARs in Vietnamese population, particularly in the South of Vietnam, and to validate our result by a meta-analysis about this topic in Vietnamese. Method: A retrospective case-control study with 37 patients treated with carbamazepine monotherapy. Statistical calculation and meta-analysis were performed by R software. Result: HLA-B*15:02 increases the risk of SJS 12.5 times higher in CBZ-treated patients (p-value = 0.017). However, this allele has no impact on MCARs (Mild Cutaneous Adverse Reactions) of CBZ. The number needed to test and the number needed to genotype is two and nine patients respectively. Conclusion: This study recommends more investigations about the cost-effectiveness of this test to accelerate the protection of Southern Vietnamese from SCARs.
摘要：
背景：日本人严格检查了HLA-B*15:02与严重皮肤不良反应之间的关系，汉族,泰国人,和高加索人。然而,关于越南人口这一主题的研究数量仍然有限，主要集中在越南北部。目的:本研究旨在阐明越南人群SCAR的遗传原因,特别是在越南南部，并通过越南语中关于这一主题的荟萃分析来验证我们的结果。方法：回顾性病例对照研究，对37例卡马西平单药治疗。采用R软件进行统计学计算和Meta分析。结果：HLA-B*15:02在CBZ治疗的患者中增加SJS的风险高12.5倍（p值=0.017）。然而,该等位基因对CBZ的MCAR（轻度皮肤不良反应）没有影响。测试所需的人数和基因型所需的人数分别为2名和9名患者。结论：本研究建议对该测试的成本效益进行更多调查，以加速保护南越免受SCAR的侵害。
