PDF(Pubmed)
Abstract：
UNASSIGNED: Athletes are at risk for developing exercise-induced lower airway narrowing. The diagnostic assessment of such lower airway dysfunction (LAD) requires an objective bronchial provocation test (BPT).
UNASSIGNED: Our primary aim was to assess if unsupervised field-based exercise challenge tests (ECTs) could confirm LAD by using app-based spirometry. We also aimed to evaluate the diagnostic test performance of field-based and sport-specific ECTs, compared with established eucapnic voluntary hyperpnoea (EVH) and methacholine BPT.
UNASSIGNED: In athletes with LAD symptoms, sensitivity and specificity analyses were performed to compare outcomes of (1) standardised field-based 8 min ECT at 85% maximal heart rate with forced expiratory volume in 1 s (FEV1) measured prechallenge and 1 min, 3 min, 5 min, 10 min, 15 min and 30 min postchallenge, (2) unstandardised field-based sport-specific ECT with FEV1 measured prechallenge and within 10 min postchallenge, (3) EVH and (4) methacholine BPT.
UNASSIGNED: Of 60 athletes (median age 17.5; range 16-28 years.; 40% females), 67% performed winter-sports, 43% reported asthma diagnosis. At least one positive BPT was observed in 68% (n=41/60), with rates of 51% (n=21/41) for standardised ECT, 49% (n=20/41) for unstandardised ECT, 32% (n=13/41) for EVH and methacholine BPT, while both standardised and unstandardised ECTs were simultaneously positive in only 20% (n=7/35). Standardised and unstandardised ECTs confirmed LAD with 54% sensitivity and 70% specificity, and 46% sensitivity and 68% specificity, respectively, using EVH as a reference, while EVH and methacholine BPT were both 33% sensitive and 85% specific, using standardised ECTs as reference.
UNASSIGNED: App-based spirometry for unsupervised field-based ECTs may support the diagnostic process in athletes with LAD symptoms.
UNASSIGNED: NCT04275648.
UNASSIGNED: Our primary aim was to assess if unsupervised field-based exercise challenge tests (ECTs) could confirm LAD by using app-based spirometry. We also aimed to evaluate the diagnostic test performance of field-based and sport-specific ECTs, compared with established eucapnic voluntary hyperpnoea (EVH) and methacholine BPT.
UNASSIGNED: In athletes with LAD symptoms, sensitivity and specificity analyses were performed to compare outcomes of (1) standardised field-based 8 min ECT at 85% maximal heart rate with forced expiratory volume in 1 s (FEV1) measured prechallenge and 1 min, 3 min, 5 min, 10 min, 15 min and 30 min postchallenge, (2) unstandardised field-based sport-specific ECT with FEV1 measured prechallenge and within 10 min postchallenge, (3) EVH and (4) methacholine BPT.
UNASSIGNED: Of 60 athletes (median age 17.5; range 16-28 years.; 40% females), 67% performed winter-sports, 43% reported asthma diagnosis. At least one positive BPT was observed in 68% (n=41/60), with rates of 51% (n=21/41) for standardised ECT, 49% (n=20/41) for unstandardised ECT, 32% (n=13/41) for EVH and methacholine BPT, while both standardised and unstandardised ECTs were simultaneously positive in only 20% (n=7/35). Standardised and unstandardised ECTs confirmed LAD with 54% sensitivity and 70% specificity, and 46% sensitivity and 68% specificity, respectively, using EVH as a reference, while EVH and methacholine BPT were both 33% sensitive and 85% specific, using standardised ECTs as reference.
UNASSIGNED: App-based spirometry for unsupervised field-based ECTs may support the diagnostic process in athletes with LAD symptoms.
UNASSIGNED: NCT04275648.
摘要：
■运动员有发生运动引起的下气道狭窄的风险。这种下气道功能障碍（LAD）的诊断评估需要客观的支气管激发试验（BPT）。
■我们的主要目的是评估无监督的基于野外的运动挑战测试（ECT）是否可以通过基于应用程序的肺活量测定法来确认LAD。我们还旨在评估基于现场和特定运动的ECT的诊断测试性能，与已建立的eucapnic自愿性呼吸亢进（EVH）和乙酰甲胆碱BPT相比。
■在有LAD症状的运动员中，进行了敏感性和特异性分析，以比较以下结果：（1）在85％最大心率下基于标准化场的8分钟ECT与1s（FEV1）测量的激发前和1分钟的用力呼气量，3分钟,5分钟,10分钟,挑战后15分钟和30分钟，(2)在挑战前和挑战后10分钟内测量FEV1的基于领域的非标准化运动特异性ECT，(3)EVH和(4)乙酰甲胆碱BPT。
■60名运动员（平均年龄17.5岁；范围16-28岁。；40%女性)，67%的人进行冬季运动，43%报告诊断为哮喘。在68%(n=41/60)中观察到至少一个阳性BPT,标准化ECT的比率为51%(n=21/41)，49％（n=20/41）用于非标准化ECT，32%(n=13/41)的EVH和乙酰甲胆碱BPT，而标准化和非标准化ECT均同时呈阳性的只有20%(n=7/35)。标准化和非标准化的ECT证实LAD具有54%的灵敏度和70%的特异性。46%的灵敏度和68%的特异性，分别,使用EVH作为参考，而EVH和乙酰甲胆碱BPT均为33%敏感性和85%特异性，使用标准化的ECT作为参考。
■用于无监督的基于现场的ECT的基于应用程序的肺活量测定可能支持患有LAD症状的运动员的诊断过程。
■NCT04275648。
■我们的主要目的是评估无监督的基于野外的运动挑战测试（ECT）是否可以通过基于应用程序的肺活量测定法来确认LAD。我们还旨在评估基于现场和特定运动的ECT的诊断测试性能，与已建立的eucapnic自愿性呼吸亢进（EVH）和乙酰甲胆碱BPT相比。
■在有LAD症状的运动员中，进行了敏感性和特异性分析，以比较以下结果：（1）在85％最大心率下基于标准化场的8分钟ECT与1s（FEV1）测量的激发前和1分钟的用力呼气量，3分钟,5分钟,10分钟,挑战后15分钟和30分钟，(2)在挑战前和挑战后10分钟内测量FEV1的基于领域的非标准化运动特异性ECT，(3)EVH和(4)乙酰甲胆碱BPT。
■60名运动员（平均年龄17.5岁；范围16-28岁。；40%女性)，67%的人进行冬季运动，43%报告诊断为哮喘。在68%(n=41/60)中观察到至少一个阳性BPT,标准化ECT的比率为51%(n=21/41)，49％（n=20/41）用于非标准化ECT，32%(n=13/41)的EVH和乙酰甲胆碱BPT，而标准化和非标准化ECT均同时呈阳性的只有20%(n=7/35)。标准化和非标准化的ECT证实LAD具有54%的灵敏度和70%的特异性。46%的灵敏度和68%的特异性，分别,使用EVH作为参考，而EVH和乙酰甲胆碱BPT均为33%敏感性和85%特异性，使用标准化的ECT作为参考。
■用于无监督的基于现场的ECT的基于应用程序的肺活量测定可能支持患有LAD症状的运动员的诊断过程。
■NCT04275648。
