{Reference Type}: Journal Article
{Title}: Unsupervised field-based exercise challenge tests to support the detection of exercise-induced lower airway dysfunction in athletes.
{Author}: Reier-Nilsen T;Stang JS;Flatsetøy H;Isachsen M;Ljungberg H;Bahr R;Nordlund B;
{Journal}: BMJ Open Sport Exerc Med
{Volume}: 9
{Issue}: 3
{Year}: 2023
暂无{DOI}: 10.1136/bmjsem-2023-001680
{Abstract}: UNASSIGNED: Athletes are at risk for developing exercise-induced lower airway narrowing. The diagnostic assessment of such lower airway dysfunction (LAD) requires an objective bronchial provocation test (BPT).
UNASSIGNED: Our primary aim was to assess if unsupervised field-based exercise challenge tests (ECTs) could confirm LAD by using app-based spirometry. We also aimed to evaluate the diagnostic test performance of field-based and sport-specific ECTs, compared with established eucapnic voluntary hyperpnoea (EVH) and methacholine BPT.
UNASSIGNED: In athletes with LAD symptoms, sensitivity and specificity analyses were performed to compare outcomes of (1) standardised field-based 8 min ECT at 85% maximal heart rate with forced expiratory volume in 1 s (FEV1) measured prechallenge and 1 min, 3 min, 5 min, 10 min, 15 min and 30 min postchallenge, (2) unstandardised field-based sport-specific ECT with FEV1 measured prechallenge and within 10 min postchallenge, (3) EVH and (4) methacholine BPT.
UNASSIGNED: Of 60 athletes (median age 17.5; range 16-28 years.; 40% females), 67% performed winter-sports, 43% reported asthma diagnosis. At least one positive BPT was observed in 68% (n=41/60), with rates of 51% (n=21/41) for standardised ECT, 49% (n=20/41) for unstandardised ECT, 32% (n=13/41) for EVH and methacholine BPT, while both standardised and unstandardised ECTs were simultaneously positive in only 20% (n=7/35). Standardised and unstandardised ECTs confirmed LAD with 54% sensitivity and 70% specificity, and 46% sensitivity and 68% specificity, respectively, using EVH as a reference, while EVH and methacholine BPT were both 33% sensitive and 85% specific, using standardised ECTs as reference.
UNASSIGNED: App-based spirometry for unsupervised field-based ECTs may support the diagnostic process in athletes with LAD symptoms.
UNASSIGNED: NCT04275648.