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Abstract：
We compared the clinical characteristics and outcome of vaccinated hospitalized COVID-19 patients with unvaccinated hospitalized COVID-19 patients. A retrospective cohort study was conducted at the Sindh Infectious Diseases Hospital and Research Center, Karachi, Pakistan. A total of 1407 hospitalized COVID-19 positive patients were included from April 2021 to March 2022, of which 812 (57.71%) were males. Of the 1407, 378 (26.87%) patients were vaccinated while 1029 (73.13%) were unvaccinated. Of the vaccinated patients, 160 (42.32%) were partially vaccinated while 218 (57.68%) were fully vaccinated (vaccine breakthrough infection). Fewer unvaccinated COVID-19 patients survived compared to vaccinated patients (62.5% vs. 70%, RR 0.89, 95% CI: 0.82-0.96, p-value = 0.004). Despite there being more vaccinated patients above 60 years of age (60.05% vs. 47.13%), their risk of mortality was lower by 43% (OR = 0.578; CI = 0.4201 to 0.7980, p = 0.0009). On survival analysis, vaccinated patients had better 30-day survival compared to unvaccinated patients (p = 0.028). Moreover, comparing waves 3-5, unvaccinated patients of wave 4, which was driven by the delta variant, had the worst survival (51.8%, p ≤ 0.001) while vaccinated patients of wave 3 (driven by the alpha variant) had the best survival (71.6%).
摘要：
我们比较了接种疫苗的住院COVID-19患者与未接种疫苗的住院COVID-19患者的临床特征和结果。在信德省传染病医院和研究中心进行了一项回顾性队列研究，卡拉奇,巴基斯坦。2021年4月至2022年3月共纳入1407例COVID-19阳性住院患者，其中男性812例（57.71%）。在1407年中，有378名（26.87％）患者接种了疫苗，而有1029名（73.13％）患者未接种疫苗。在接种疫苗的患者中，160（42.32％）部分接种，而218（57.68％）完全接种（疫苗突破感染）。与接种疫苗的患者相比，未接种疫苗的COVID-19患者的存活人数更少(62.5%vs.70%,RR0.89，95%CI：0.82-0.96，p值=0.004）。尽管有更多60岁以上的接种疫苗的患者（60.05％vs.47.13%），他们的死亡风险降低了43%(OR=0.578;CI=0.4201~0.7980,p=0.0009).关于生存分析，与未接种疫苗的患者相比，接种疫苗的患者具有更好的30天生存率（p=0.028）。此外，比较第3-5波，第4波未接种疫苗的患者，这是由三角洲变异体驱动的，生存率最差(51.8%，p≤0.001），而第3波（由α变体驱动）的疫苗接种患者的生存率最好（71.6％）。
