PDF(Pubmed)
Abstract：
(1) Background: Amblyopia is an ocular condition leading to structural and functional changes. The relationship between these changes is complex and remains poorly understood. (2) Methods: Participants included 31 children aged 5 to 9 years with strabismic (n = 9), anisometropic (n = 16) and mixed (n = 6) unilateral amblyopia, and 14 age-matched non-amblyopic children. The 95% and 63% Bivariate Contour Ellipse Area (BCEA), axial length, Foveal Avascular Zone (FAZ) area, center macular thickness and volume were assessed. The relationship between these parameters was explored. (3) Results: Statistically significant differences were found among the four groups in best corrected distance visual acuity (BCVA) (p < 0.001), BCEA 95% (p = 0.002) and BCEA 63% (p = 0.002), but not in the FAZ area, central macular thickness, central macular volume and axial length. Eyes with amblyopia had poorer BCVA and larger fixation instability than controls. Inter-ocular differences were more significant in patients with strabismic amblyopia, particularly in BCVA (p = 0.003), central macular thickness (p < 0.001) and central macular volume (p = 0.002). In amblyopic eyes, BCEA 95% and 63% were correlated with BCVA, but not with the FAZ area. (4) Conclusion: Amblyopia is associated with a reduction in fixation stability and BCVA, although there is a general lack of correlation with structural changes, suggesting a complex interaction between anatomy and function in amblyopia.
摘要：
（1）背景：弱视是一种导致结构和功能改变的眼部疾病。这些变化之间的关系是复杂的，仍然知之甚少。(2)方法:研究对象包括31名5~9岁斜视儿童(n=9),屈光参差（n=16）和混合（n=6）单侧弱视，和14名年龄匹配的非弱视儿童。95%和63%的二元轮廓椭圆面积(BCEA)，轴向长度,中央凹无血管区（FAZ）区域；评估黄斑中心厚度和体积.探索了这些参数之间的关系。(3)结果:四组最佳矫正视力(BCVA)差异有统计学意义(p<0.001),BCEA95%（p=0.002）和BCEA63%（p=0.002），但不是在FAZ地区,黄斑中心厚度,中央黄斑体积和轴向长度。与对照组相比，弱视眼睛的BCVA较差，固定不稳定性更大。斜视性弱视患者的眼间差异更显著，特别是在BCVA中(p=0.003)，黄斑中心厚度（p<0.001）和黄斑中心体积（p=0.002）。在弱视的眼睛里，BCEA95%和63%与BCVA相关，但不是FAZ地区。（4）结论：弱视与固定稳定性和BCVA降低有关，尽管与结构变化普遍缺乏相关性，表明弱视的解剖结构和功能之间存在复杂的相互作用。
