PDF(Pubmed)
Abstract：
Non-coding RNAs (ncRNAs) are, arguably, the enigma of the RNA transcriptome. Even though there are more annotated ncRNAs (25,967) compared to mRNAs (19,827), we know far less about each of the genes that produce ncRNA, especially in terms of their regulation, molecular functions, and interactions. Further, we are only beginning to understand the role of differential regulation or function of ncRNAs caused by genetic and epigenetic perturbations, such as single nucleotide variants (SNV), deletions, insertions, and histone/DNA modifications. The 22 papers in this Special Issue describe the emerging roles of ncRNAs in neurological, cardiovascular, immune, and hepatic systems, to name a few, as well as in diseases such as cancer, Prader-Willi Syndrome, cardiac arrhythmias, and diabetes. As we begin to understand the function and regulation of this class of RNAs, strategies targeting ncRNAs could lead to improved therapeutic interventions for some conditions.
摘要：
非编码RNA(ncRNAs)是，可以说,RNA转录组的谜团。尽管与mRNA（19,827）相比，有更多注释的ncRNAs（25,967），我们对产生ncRNA的每个基因知之甚少，特别是在他们的监管方面，分子功能，和互动。Further,我们才刚刚开始了解由遗传和表观遗传扰动引起的ncRNAs的差异调节或功能的作用，例如单核苷酸变体（SNV），删除,插入,和组蛋白/DNA修饰。本期特刊中的22篇论文描述了ncRNAs在神经学中的新兴作用，心血管,免疫，和肝脏系统，举几个例子,以及癌症等疾病，Prader-Willi综合征,心律失常,和糖尿病。当我们开始了解这类RNA的功能和调控时，针对ncRNAs的策略可以改善某些疾病的治疗干预。
