PDF(Pubmed)
Abstract：
Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis. Tumor cells overexpress peptide receptors, crucial targets for developing specific treatments against cancer cells using peptide receptor antagonists and promoting apoptosis in tumor cells. Opioids exert an antitumoral effect, whereas others promote tumor growth and metastasis. This review updates the findings regarding the involvement of opioid peptides (enkephalins, endorphins, and dynorphins) in cancer development. Anticancer therapeutic strategies targeting the opioid peptidergic system and the main research lines to be developed regarding the topic reviewed are suggested. There is much to investigate about opioid peptides and cancer: basic information is scarce, incomplete, or absent in many tumors. This knowledge is crucial since promising anticancer strategies could be developed alone or in combination therapies with chemotherapy/radiotherapy.
摘要：
肽介导有利于有丝分裂发生的癌症进展，迁移,和肿瘤细胞的侵袭，促进转移和抗凋亡机制，并促进血管生成/淋巴管生成。肿瘤细胞过表达肽受体,使用肽受体拮抗剂开发针对癌细胞的特异性治疗和促进肿瘤细胞凋亡的关键靶标。阿片类药物发挥抗肿瘤作用，而其他促进肿瘤生长和转移。这篇综述更新了有关阿片类肽（脑啡肽，内啡肽,和强啡肽）在癌症发展中。提出了针对阿片肽能系统的抗癌治疗策略，以及有关该主题的主要研究方向。关于阿片类肽和癌症的研究很多：基本信息很少，不完整,或在许多肿瘤中不存在。这些知识至关重要，因为有希望的抗癌策略可以单独开发或与化学疗法/放射疗法联合开发。
