PDF(Pubmed)
Abstract：
Turpentine oil, owing to the presence of 7-50 terpenes, has analgesic, anti-inflammatory, immunomodulatory, antibacterial, anticoagulant, antioxidant, and antitumor properties, which are important for medical emulsion preparation. The addition of turpentine oil to squalene emulsions can increase their effectiveness, thereby reducing the concentration of expensive and possibly deficient squalene, and increasing its stability and shelf life. In this study, squalene emulsions were obtained by adding various concentrations of turpentine oil via high-pressure homogenization, and the safety and effectiveness of the obtained emulsions were studied in vitro and in vivo. All emulsions showed high safety profiles, regardless of the concentration of turpentine oil used. However, these emulsions exhibited dose-dependent effects in terms of both efficiency and storage stability, and the squalene emulsion with 1.0% turpentine oil had the most pronounced adjuvant and cytokine-stimulating activity as well as the most pronounced stability indicators when stored at room temperature. Thus, it can be concluded that the squalene emulsion with 1% turpentine oil is a stable, monomodal, and reliably safe ultradispersed emulsion and may have pleiotropic effects with pronounced immunopotentiating properties.
摘要：
松节油,由于存在7-50萜烯，有止痛药，抗炎,免疫调节,抗菌，抗凝剂,抗氧化剂，和抗肿瘤特性，这对于医用乳液的制备很重要。在角鲨烯乳液中添加松节油可以提高其有效性，从而降低昂贵且可能不足的角鲨烯的浓度，并增加其稳定性和保质期。在这项研究中,角鲨烯乳液是通过高压均质添加各种浓度的松节油获得的，并在体外和体内研究了所得乳剂的安全性和有效性。所有乳液都显示出很高的安全性，无论使用松节油的浓度。然而,这些乳液在效率和储存稳定性方面都表现出剂量依赖性效应，含1.0%松节油的角鲨烯乳液在室温下储存时具有最显著的佐剂和细胞因子刺激活性以及最显著的稳定性指标。因此，可以得出结论，含1%松节油的角鲨烯乳液是一种稳定的，单峰,和可靠的安全超分散乳液，可能具有多效性，具有明显的免疫增强特性。
