PDF(Pubmed)
Abstract：
Toll-like receptors (TLRs) have a critical role in the pathogenesis and disease course of viral infections. The induced pro-inflammatory responses result in the disturbance of the endovascular surface layer and impair vascular homeostasis. The injury of the vessel wall further promotes pro-thrombotic and pro-coagulatory processes, eventually leading to micro-vessel plugging and tissue necrosis. Moreover, TLRs have a direct role in the sensing of viruses and platelet activation. TLR-mediated upregulation of von Willebrand factor release and neutrophil, as well as macrophage extra-cellular trap formation, further contribute to (micro-) thrombotic processes during inflammation. The following review focuses on TLR signaling pathways of TLRs expressed in humans provoking pro-thrombotic responses, which determine patient outcome during viral infections, especially in those with cardiovascular diseases.
摘要：
Toll样受体(TLRs)在病毒感染的发病机制和病程中起着至关重要的作用。诱导的促炎反应导致血管内表面层的紊乱并损害血管内稳态。血管壁的损伤进一步促进促血栓形成和促凝血过程，最终导致微血管堵塞和组织坏死。此外，TLRs在病毒的传感和血小板活化中具有直接感化。TLR介导的血管性血友病因子释放和中性粒细胞的上调，以及巨噬细胞胞外陷阱的形成，进一步有助于炎症期间的（微）血栓形成过程。以下综述集中于在人类中表达的TLRs引起促血栓形成反应的TLR信号通路。决定患者在病毒感染期间的预后，尤其是那些有心血管疾病的人。
