PDF(Pubmed)
Abstract：
Photodynamic therapy (PDT) is a clinically approved minimally/non-invasive treatment modality that has been used to treat various conditions, including cancer. The bystander and abscopal effects are two well-documented significant reactions involved in imparting long-term systemic effects in the field of radiobiology. The PDT-induced generation of reactive oxygen and nitrogen species and immune responses is majorly involved in eliciting the bystander and abscopal effects. However, the results in this regard are unsatisfactory and unpredictable due to several poorly elucidated underlying mechanisms and other factors such as the type of cancer being treated, the irradiation dose applied, the treatment regimen employed, and many others. Therefore, in this review, we attempted to summarize the current knowledge regarding the non-targeted effects of PDT. The review is based on research published in the Web of Science, PubMed, Wiley Online Library, and Google Scholar databases up to June 2023. We have highlighted the current challenges and prospects in relation to obtaining clinically relevant robust, reproducible, and long-lasting antitumor effects, which may offer a clinically viable treatment against tumor recurrence and metastasis. The effectiveness of both targeted and untargeted PDT responses and their outcomes in clinics could be improved with more research in this area.
摘要：
光动力疗法（PDT）是一种临床批准的微创/无创治疗方式，已用于治疗各种疾病，包括癌症.旁观效应和远观效应是在放射生物学领域赋予长期全身效应的两个有据可查的重要反应。PDT诱导的活性氧和氮物质的产生以及免疫反应主要参与引发旁观者和旁观效应。然而,在这方面的结果是不令人满意的和不可预测的，由于一些不清楚的潜在机制和其他因素，如癌症治疗的类型，所施加的辐照剂量，采用的治疗方案，和许多其他人。因此,在这次审查中,我们试图总结目前有关PDT非靶向效应的知识.该评论基于发表在WebofScience上的研究，PubMed,Wiley在线图书馆,和截至2023年6月的谷歌学者数据库。我们强调了当前的挑战和前景，与获得临床相关的健壮，可重复,和持久的抗肿瘤作用，这可能提供临床上可行的治疗肿瘤复发和转移。靶向和非靶向PDT反应的有效性及其在临床中的结果可以通过在该领域的更多研究来改善。
