PDF(Pubmed)
Abstract：
Inflammasomes are cytoplasmic organelles that stimulate inflammation upon cellular detection of infectious or non-infectious stress. While much foundational work has focused on the infection-associated aspects of inflammasome activities, recent studies have highlighted the role of inflammasomes in non-infectious cellular and organismal functions. Herein, we discuss the evolution of inflammasome components and highlight characteristics that permit inflammasome regulation of physiologic processes. We focus on emerging data that highlight the importance of inflammasome proteins in the regulation of reproduction, development, and malignancy. A framework is proposed to contextualize these findings.
摘要：
炎性体是在细胞检测到感染性或非感染性应激时刺激炎症的细胞质细胞器。虽然许多基础工作都集中在炎症体活动的感染相关方面，最近的研究强调了炎性体在非感染性细胞和机体功能中的作用。在这里，我们讨论了炎症小体成分的进化，并强调了允许炎症小体调节生理过程的特征。我们专注于新出现的数据，这些数据突出了炎症小体蛋白在生殖调节中的重要性，发展,和恶性肿瘤。提出了一个框架来说明这些发现的背景。
