PDF(Pubmed)
Abstract：
Emulsion-based systems that combine natural polymers with vegetable oils have been identified as a promising research avenue for developing structures with potential for biomedical applications. Herein, chitosan (CHT), a natural polymer, and virgin coconut oil (VCO), a resource obtained from coconut kernels, were combined to create an emulsion system. Phytantriol-based cubosomes encapsulating sodium diclofenac, an anti-inflammatory drug, were further dispersed into CHT/VCO- based emulsion. Then, the emulsions were frozen and freeze-dried to produce scaffolds. The scaffolds had a porous structure ranging from 20.4 to 73.4 µm, a high swelling ability (up to 900%) in PBS, and adequate stiffness, notably in the presence of cubosomes. Moreover, a well-sustained release of the entrapped diclofenac in the cubosomes into the CHT/VCO-based system, with an accumulated release of 45 ± 2%, was confirmed in PBS, compared to free diclofenac dispersed (80 ± 4%) into CHT/VCO-based structures. Overall, the present approach opens up new avenues for designing porous biomaterials for drug delivery through a sustainable pathway.
摘要：
将天然聚合物与植物油结合的基于乳液的系统已被确定为开发具有生物医学应用潜力的结构的有前途的研究途径。在这里，壳聚糖（CHT），一种天然聚合物,和初榨椰子油（VCO），从椰子仁获得的资源，组合以创建乳液系统。基于植三醇的立方体封装双氯芬酸钠，一种抗炎药,进一步分散到CHT/VCO-基乳液中。然后，将乳液冷冻并冷冻干燥以产生支架。支架的多孔结构范围为20.4至73.4µm，在PBS中具有高溶胀能力（高达900％），和足够的刚度，特别是在立方体存在的情况下。此外，在基于CHT/VCO的系统中充分持续地释放在立方体中的双氯芬酸,累积释放量为45±2%，在PBS中得到证实，与分散在CHT/VCO基结构中的游离双氯芬酸(80±4%)相比。总的来说,本方法为通过可持续途径设计用于药物递送的多孔生物材料开辟了新的途径。
