PDF(Pubmed)
Abstract：
BACKGROUND: Zinc L-carnosine promotes the transition from the inflammatory to the proliferative phase of wound healing by reducing the expression of pro-inflammatory signals and enhancing the expression of anti-inflammatory signals. This prospective cohort study aims to test the effect of a zinc-L-carnosine mouthwash in promoting oral surgical wound healing.
METHODS: From October 2022 to February 2023, the authors enrolled healthy adult volunteers who needed the extraction of bilateral molars at the Unit of Dentistry of the University of Bari. The authors studied the baseline wound healing of each patient after the first extraction. Three months later, the patients underwent the second extraction and rinsed their mouths with zinc-L-carnosine mouthwash twice per day for the following 28 postoperative days. For a month after each extraction, the patients received weekly follow-up visits by an oral surgeon blinded about the study to record the modified healing index score of the wounds (range 0-6 points). For statistical analysis, we used the one-tailed t-test for paired samples with a significance level set at p < 0.05 to compare the baseline scores with those recorded during the exposure to the zinc-L-carnosine mouthwash.
RESULTS: The authors enrolled four women and six men (mean age = 44.60 ± 19.22 years). On the seventh and fourteenth postoperative days, the mean difference between the modified healing index scores obtained by using the zinc-L-carnosine mouthwash and the baseline was not significant. On the twenty-first postoperative day, the mean score obtained by using the mouthwash was 5.2 ± 1.3 points and was significantly higher than the 4.7 ± 1.8 points of the baseline (p = 0.026). On the twenty-eighth postoperative day, the mean difference was significant as well (5.9 ± 0.3 points and 5.4 ± 1.1 points, respectively).
CONCLUSIONS: The preliminary results of this study showed that the zinc-L-carnosine mouthwash improved the quality of oral surgical wound healing.
METHODS: From October 2022 to February 2023, the authors enrolled healthy adult volunteers who needed the extraction of bilateral molars at the Unit of Dentistry of the University of Bari. The authors studied the baseline wound healing of each patient after the first extraction. Three months later, the patients underwent the second extraction and rinsed their mouths with zinc-L-carnosine mouthwash twice per day for the following 28 postoperative days. For a month after each extraction, the patients received weekly follow-up visits by an oral surgeon blinded about the study to record the modified healing index score of the wounds (range 0-6 points). For statistical analysis, we used the one-tailed t-test for paired samples with a significance level set at p < 0.05 to compare the baseline scores with those recorded during the exposure to the zinc-L-carnosine mouthwash.
RESULTS: The authors enrolled four women and six men (mean age = 44.60 ± 19.22 years). On the seventh and fourteenth postoperative days, the mean difference between the modified healing index scores obtained by using the zinc-L-carnosine mouthwash and the baseline was not significant. On the twenty-first postoperative day, the mean score obtained by using the mouthwash was 5.2 ± 1.3 points and was significantly higher than the 4.7 ± 1.8 points of the baseline (p = 0.026). On the twenty-eighth postoperative day, the mean difference was significant as well (5.9 ± 0.3 points and 5.4 ± 1.1 points, respectively).
CONCLUSIONS: The preliminary results of this study showed that the zinc-L-carnosine mouthwash improved the quality of oral surgical wound healing.
摘要：
背景:L-肌肽锌通过减少促炎信号的表达和增强抗炎信号的表达来促进伤口愈合从炎性阶段向增殖阶段的转变。这项前瞻性队列研究旨在测试锌-L-肌肽漱口水促进口腔手术伤口愈合的效果。
方法：从2022年10月到2023年2月，作者在巴里大学牙科部门招募了需要提取双侧磨牙的健康成年志愿者。作者研究了第一次拔牙后每位患者的基线伤口愈合情况。三个月后,在术后28天,患者接受了第二次拔除,并每天两次用锌-L-肌肽漱口水漱口.每次提取后一个月，患者每周接受口腔外科医师的随访,该医师对研究不了解,记录伤口的改良愈合指数评分(0~6分).为了进行统计分析，我们对成对样本使用单尾t检验,显著性水平设定为p<0.05,以将基线评分与暴露于锌-L-肌肽漱口水期间记录的评分进行比较。
结果：作者招募了4名女性和6名男性（平均年龄=44.60±19.22岁）。在术后第7天和第14天，使用锌-L-肌肽漱口水获得的改良愈合指数评分与基线之间的平均差异不显著.术后第21天,使用漱口水获得的平均评分为5.2±1.3分,显著高于基线的4.7±1.8分(p=0.026).术后第28天,平均差异也有统计学意义(5.9±0.3分和5.4±1.1分，分别)。
结论：这项研究的初步结果表明，锌-L-肌肽漱口水改善了口腔手术伤口愈合的质量。
方法：从2022年10月到2023年2月，作者在巴里大学牙科部门招募了需要提取双侧磨牙的健康成年志愿者。作者研究了第一次拔牙后每位患者的基线伤口愈合情况。三个月后,在术后28天,患者接受了第二次拔除,并每天两次用锌-L-肌肽漱口水漱口.每次提取后一个月，患者每周接受口腔外科医师的随访,该医师对研究不了解,记录伤口的改良愈合指数评分(0~6分).为了进行统计分析，我们对成对样本使用单尾t检验,显著性水平设定为p<0.05,以将基线评分与暴露于锌-L-肌肽漱口水期间记录的评分进行比较。
结果：作者招募了4名女性和6名男性（平均年龄=44.60±19.22岁）。在术后第7天和第14天，使用锌-L-肌肽漱口水获得的改良愈合指数评分与基线之间的平均差异不显著.术后第21天,使用漱口水获得的平均评分为5.2±1.3分,显著高于基线的4.7±1.8分(p=0.026).术后第28天,平均差异也有统计学意义(5.9±0.3分和5.4±1.1分，分别)。
结论：这项研究的初步结果表明，锌-L-肌肽漱口水改善了口腔手术伤口愈合的质量。
