UNASSIGNED: This randomized, double-blind, cross-over, and placebo-controlled trial involved 12 young, healthy male water polo athletes. After daily training for seven days, they ingested either olive fruit extract, containing 60 mg/day MA, or a placebo. We measured perceptual fatigue and muscle soreness during the intervention using a visual analog scale and inflammatory and oxidative stress-related proteins.
UNASSIGNED: Perceptual fatigue and muscle soreness and the area under the curve during the training period were significantly lower (main effect of MA; P < 0.05) following MA supplementation than those for the placebo. MA supplementation during training lowered perceptual fatigue and muscle soreness by decreasing inflammatory factors in water polo athletes. Additionally, we examined the detailed mechanism of MA, added the participant\'s serum to the culture medium at a 10% concentration to determine inflammation- and oxidative stress-related intracellular signals. Skeletal muscle cells (C2C12) cultured with MA-conditioned serum before and after intervention also suppressed expression of inflammation and oxidative stress-related proteins.
UNASSIGNED: These findings suggest that MA intake not only reduces perceptual fatigue and muscle soreness but also decreases inflammation and oxidative stress in the blood and skeletal muscle.
■这是随机的,双盲,cross-over,安慰剂对照试验涉及12名年轻人,健康的男性水球运动员。经过七天的日常训练,他们摄入了橄榄果实提取物,含有60毫克/天的MA,或者安慰剂.我们使用视觉模拟量表以及炎症和氧化应激相关蛋白测量了干预期间的知觉疲劳和肌肉酸痛。
■补充MA后,训练期间的知觉疲劳和肌肉酸痛以及曲线下面积显着低于安慰剂(MA的主要作用;P<0.05)。训练期间补充MA可通过降低水球运动员的炎症因子来降低知觉疲劳和肌肉酸痛。此外,我们研究了MA的详细机制,将参与者的血清以10%的浓度添加到培养基中,以确定炎症和氧化应激相关的细胞内信号。在干预前后,用MA条件血清培养的骨骼肌细胞(C2C12)也抑制了炎症和氧化应激相关蛋白的表达。
■这些发现表明,MA的摄入不仅可以减少知觉疲劳和肌肉酸痛,而且可以减少血液和骨骼肌中的炎症和氧化应激。