OBJECTIVE: The objective was to compare the haemostatic status of dogs with liver tumours and healthy control dogs, by comparing coagulation and thromboelastography (TEG) measurements at three time points.
METHODS: Liver tumour and healthy control dogs receiving surgery for liver lobectomy and ovariohysterectomy, respectively, were prospectively enrolled. All dogs had blood collected at three time points: pre-operative, 24 h post-operative and ~2 weeks post-operative. Haematological and haemostatic values were compared across time points in each group using repeated measures ANOVA tests.
RESULTS: Ten and eight dogs were enrolled for the liver and control groups, respectively. Platelet count was significantly higher in the liver group than the control group at all time points, but within the normal range (pre-operative: 438.7 vs. 300.9 × 109 /L, p = .0078; 24 h post-operative: 416.2 vs. 283.9 × 109 /L, p = .0123; 10-14 days post-operative: 524.6 vs. 317.3 × 109 /L, p = .0072). The measure of the overall coagulant state (G-value) was significantly increased for the liver group compared to the control group at all time points (pre-operative: 15.6 vs. 8.6 d/sc, p = .0003; 24 h post-operative: 18.3 vs. 11.2 d/sc, p = .039; 10-14 days post-operative: 15.1 vs. 9.6 d/sc, p = .015).
CONCLUSIONS: The liver group was hypercoagulable based on elevated G-values at all time points compared to the control group. This hypercoagulability was attributed to the effect of hepatic tumours alone, and not secondary to surgery and anaesthesia.
目的:目的是比较肝脏肿瘤犬和健康对照犬的止血状态,通过比较三个时间点的凝血和血栓弹力图(TEG)测量结果。
方法:接受肝叶切除和卵巢子宫切除手术的肝肿瘤和健康对照犬,分别,被前瞻性登记。所有的狗都在三个时间点收集血液:术前,术后24小时和术后~2周。使用重复测量ANOVA测试在各组的时间点比较血液和止血值。
结果:10只和8只狗被纳入肝脏组和对照组,分别。肝组各时间点血小板计数均显著高于对照组,但在正常范围内(术前:438.7vs.300.9×109/L,p=.0078;术后24小时:416.2vs.283.9×109/L,p=.0123;术后10-14天:524.6vs.317.3×109/L,p=.0072)。在所有时间点,与对照组相比,肝脏组的总体凝血状态(G值)的测量值均显着增加(术前:15.6vs.8.6d/sc,p=.0003;术后24小时:18.3vs.11.2d/sc,p=.039;术后10-14天:15.1vs.9.6天/SC,p=.015)。
结论:与对照组相比,肝脏组在所有时间点的G值升高均为高凝状态。这种高凝状态归因于单独的肝肿瘤的作用,而不是继发于手术和麻醉。