PDF(Pubmed)
Abstract：
BACKGROUND Although arachnoid cysts are common lesions, the pathogenesis of their continuous growth remains unclear. We aimed to identify the role of aquaporins in arachnoid cyst specimens. CASE REPORT We selected 3 cases from our own facility and examined arachnoid cyst wall specimens, which were sampled intraoperatively. Patients presented with variable symptoms, a 52-year-old man with a \"heavy sensation\" in the head and dysesthesia on the left hand, a 68-year-old man with unsteady gait, and finally a 26-year-old woman with a history of intermittent headaches for 10 years. Intraoperative specimens were obtained and examined. Evaluation techniques were light microscopy, immunohistochemical staining for aquaporin, and electron microscopy. Light microscopy showed that cells were arranged in epithelium-like structures forming several thick lamellae, with visible connective tissue among them. Under electron microscopic examination, cells with many or few cell organelles and with spindle-like nuclei were arranged in lamellar or flattened structures. Many vacuolizations were seen in between. Interdigitation of cells and many desmosomes were observed. All 3 cases were positive for aquaporin 1. CONCLUSIONS Our study showed that water transportation through aquaporin 1 has a potential role in the formation and expansion of arachnoid cysts.
摘要：
背景技术尽管蛛网膜囊肿是常见的病变,其持续生长的发病机制尚不清楚。我们旨在确定水通道蛋白在蛛网膜囊肿标本中的作用。病例报告我们从自己的设施中选择了3例，并检查了蛛网膜囊肿壁标本，在术中取样。患者表现出不同的症状，一名52岁的男子，头部有“沉重的感觉”，左手有感觉，一个68岁的男子步态不稳,最后是一名26岁的女性，有10年的间歇性头痛史。获得并检查术中标本。评估技术是光学显微镜，水通道蛋白的免疫组织化学染色，和电子显微镜。光学显微镜显示细胞排列在上皮样结构中，形成几个厚的薄片，其中有可见的结缔组织。在电子显微镜检查下，具有许多或很少细胞器和纺锤状核的细胞排列成层状或扁平结构。在两者之间看到了许多空泡。观察到细胞和许多桥粒的交叉。3例均为水通道蛋白1阳性。结论我们的研究表明，通过水通道蛋白1的水运输在蛛网膜囊肿的形成和扩张中具有潜在的作用。
