Abstract：
To evaluate the efficacy and safety of hypochlorous acid (HOCI) eye drops in the treatment of fungal keratitis.
A total of 96 patients (96 eyes) with fungal keratitis were randomly divided into two groups: group Ι (conventional treatment + topical HOCI eye drops); The group II (conventional treatment). According to its severity, those patients were divided into grade Ι or grade II. Use of fungal scraping and culture to identify the type of fungal infection, slit lamp examination, and corneal fluorescein staining to observe regression, and confocal corneal microscopy to assess fungal mycelial changes. The main outcome measures were the success rate, healing time, visual recovery, and complications. The Kaplan-Meier curve method was used to analysis of the survival function of days to cure between the two groups.
There were no statistical differences between the two groups in terms of general condition, medical history, and grading. Corneal scraping results showed that all patients had filamentous fungi. For grade Ι patients, all patients were cured, and the patients in Group I showed faster healing speed than that in Group II (t = -3.665, p < .01). For grade II patients, the recovery time (t = -4.121, p < .01) and the disappearance of hypopyon (t = -4.291, p < .01) were significantly faster in the combination group. In grade Ι and II patients, the final visual acuity and the incidence of complications such as corneal neovascularization, cataract, and hyphema showed no differences in both groups. The survival curve showed that the healing rate of ulcers in the combination treatment group was faster than that in the conventional treatment group (χ2 = 14.332, p = .001).
HOCI can accelerate the healing of fungal keratitis without obvious complications, indicating a promising future in the field of keratitis treatment.
A total of 96 patients (96 eyes) with fungal keratitis were randomly divided into two groups: group Ι (conventional treatment + topical HOCI eye drops); The group II (conventional treatment). According to its severity, those patients were divided into grade Ι or grade II. Use of fungal scraping and culture to identify the type of fungal infection, slit lamp examination, and corneal fluorescein staining to observe regression, and confocal corneal microscopy to assess fungal mycelial changes. The main outcome measures were the success rate, healing time, visual recovery, and complications. The Kaplan-Meier curve method was used to analysis of the survival function of days to cure between the two groups.
There were no statistical differences between the two groups in terms of general condition, medical history, and grading. Corneal scraping results showed that all patients had filamentous fungi. For grade Ι patients, all patients were cured, and the patients in Group I showed faster healing speed than that in Group II (t = -3.665, p < .01). For grade II patients, the recovery time (t = -4.121, p < .01) and the disappearance of hypopyon (t = -4.291, p < .01) were significantly faster in the combination group. In grade Ι and II patients, the final visual acuity and the incidence of complications such as corneal neovascularization, cataract, and hyphema showed no differences in both groups. The survival curve showed that the healing rate of ulcers in the combination treatment group was faster than that in the conventional treatment group (χ2 = 14.332, p = .001).
HOCI can accelerate the healing of fungal keratitis without obvious complications, indicating a promising future in the field of keratitis treatment.
摘要：
■评估次氯酸（HOCI）滴眼液治疗真菌性角膜炎的疗效和安全性。
■将96例(96只眼)真菌性角膜炎患者随机分为两组:I组(常规治疗+局部HOCI滴眼液);II组(常规治疗)。根据其严重程度,这些患者分为I级或II级。使用真菌刮擦和培养鉴定真菌感染的类型，裂隙灯检查,和角膜荧光素染色观察消退，和共聚焦角膜显微镜来评估真菌菌丝体的变化。主要结果指标是成功率，愈合时间,视觉恢复,和并发症。采用Kaplan-Meier曲线法分析两组患者治愈天数的生存功能。
■两组一般情况无统计学差异,病史,和分级。角膜刮除结果显示所有患者均有丝状真菌。对于1级患者，所有病人都治愈了,I组患者的愈合速度快于II组（t=-3.665，p<0.01）。对于II级患者，联合组恢复时间(t=-4.121,p<.01)和低管膜消失时间(t=-4.291,p<.01)明显加快。在1级和II级患者中，最终视力和并发症的发生率，如角膜新生血管，白内障,和前房积血在两组中没有差异。生存曲线显示,联合治疗组溃疡愈合速度快于常规治疗组(χ2=14.332,p=0.001)。
■HOCI可加速真菌性角膜炎的愈合，无明显并发症，表明在角膜炎治疗领域有希望的未来。
■将96例(96只眼)真菌性角膜炎患者随机分为两组:I组(常规治疗+局部HOCI滴眼液);II组(常规治疗)。根据其严重程度,这些患者分为I级或II级。使用真菌刮擦和培养鉴定真菌感染的类型，裂隙灯检查,和角膜荧光素染色观察消退，和共聚焦角膜显微镜来评估真菌菌丝体的变化。主要结果指标是成功率，愈合时间,视觉恢复,和并发症。采用Kaplan-Meier曲线法分析两组患者治愈天数的生存功能。
■两组一般情况无统计学差异,病史,和分级。角膜刮除结果显示所有患者均有丝状真菌。对于1级患者，所有病人都治愈了,I组患者的愈合速度快于II组（t=-3.665，p<0.01）。对于II级患者，联合组恢复时间(t=-4.121,p<.01)和低管膜消失时间(t=-4.291,p<.01)明显加快。在1级和II级患者中，最终视力和并发症的发生率，如角膜新生血管，白内障,和前房积血在两组中没有差异。生存曲线显示,联合治疗组溃疡愈合速度快于常规治疗组(χ2=14.332,p=0.001)。
■HOCI可加速真菌性角膜炎的愈合，无明显并发症，表明在角膜炎治疗领域有希望的未来。
