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Abstract：
Neurexin-3 is primarily localized in the presynaptic membrane and forms complexes with various ligands located in the postsynaptic membrane. Neurexin-3 has important roles in synapse development and synapse functions. Neurexin-3 mediates excitatory presynaptic differentiation by interacting with leucine-rich-repeat transmembrane neuronal proteins. Meanwhile, neurexin-3 modulates the expression of presynaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors and γ-aminobutyric acid A receptors by interacting with neuroligins at excitatory and inhibitory synapses. Numerous studies have documented the potential contribution of neurexin-3 to neurodegenerative and neuropsychiatric disorders, such as Alzheimer\'s disease, addiction behaviors, and other diseases, which raises hopes that understanding the mechanisms of neurexin-3 may hold the key to developing new strategies for related illnesses. This review comprehensively covers the literature to provide current knowledge of the structure, function, and clinical role of neurexin-3.
摘要：
Neurexin-3主要位于突触前膜中，并与位于突触后膜中的各种配体形成复合物。Neurexin-3在突触发育和突触功能中具有重要作用。Neurexin-3通过与富含亮氨酸的重复跨膜神经元蛋白相互作用介导兴奋性突触前分化。同时,neurexin-3通过在兴奋性和抑制性突触中与神经素相互作用来调节突触前α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体和γ-氨基丁酸A受体的表达。许多研究已经记录了新尿嘧啶-3对神经退行性疾病和神经精神疾病的潜在贡献。如老年痴呆症,成瘾行为,和其他疾病，这引起了人们的希望，即了解neurexin-3的机制可能是制定相关疾病新策略的关键。这篇综述全面涵盖了文献，以提供有关结构的最新知识，函数,和neurexin-3的临床作用。
