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Abstract：
We compared white matter hyperintensities (WMHs) in early-onset Alzheimer\'s disease (EOAD) with cognitively normal (CN) and early-onset amyloid-negative cognitively impaired (EOnonAD) groups in the Longitudinal Early-Onset Alzheimer\'s Disease Study.
We investigated the role of increased WMH in cognition and amyloid and tau burden. We compared WMH burden of 205 EOAD, 68 EOnonAD, and 89 CN participants in lobar regions using t-tests and analyses of covariance. Linear regression analyses were used to investigate the association between WMH and cognitive impairment and that between amyloid and tau burden.
EOAD showed greater WMHs compared with CN and EOnonAD participants across all regions with no significant differences between CN and EOnonAD groups. Greater WMHs were associated with worse cognition. Tau burden was positively associated with WMH burden in the EOAD group.
EOAD consistently showed higher WMH volumes. Overall, greater WMHs were associated with worse cognition and higher tau burden in EOAD.
This study represents a comprehensive characterization of WMHs in sporadic EOAD. WMH volumes are associated with tau burden from positron emission tomography (PET) in EOAD, suggesting WMHs are correlated with increasing burden of AD. Greater WMH volumes are associated with worse performance on global cognitive tests. EOAD participants have higher WMH volumes compared with CN and early-onset amyloid-negative cognitively impaired (EOnonAD) groups across all brain regions.
We investigated the role of increased WMH in cognition and amyloid and tau burden. We compared WMH burden of 205 EOAD, 68 EOnonAD, and 89 CN participants in lobar regions using t-tests and analyses of covariance. Linear regression analyses were used to investigate the association between WMH and cognitive impairment and that between amyloid and tau burden.
EOAD showed greater WMHs compared with CN and EOnonAD participants across all regions with no significant differences between CN and EOnonAD groups. Greater WMHs were associated with worse cognition. Tau burden was positively associated with WMH burden in the EOAD group.
EOAD consistently showed higher WMH volumes. Overall, greater WMHs were associated with worse cognition and higher tau burden in EOAD.
This study represents a comprehensive characterization of WMHs in sporadic EOAD. WMH volumes are associated with tau burden from positron emission tomography (PET) in EOAD, suggesting WMHs are correlated with increasing burden of AD. Greater WMH volumes are associated with worse performance on global cognitive tests. EOAD participants have higher WMH volumes compared with CN and early-onset amyloid-negative cognitively impaired (EOnonAD) groups across all brain regions.
摘要：
背景：在纵向早发阿尔茨海默病研究中，我们比较了早发性阿尔茨海默病（EOAD）与认知正常（CN）和早发性淀粉样蛋白阴性认知障碍（EOnononAD）组的白质高信号（WMHs）。
方法：我们研究了WMH增加在认知和淀粉样蛋白和tau负担中的作用。我们比较了205EOAD的WMH负担，68EOnonAD，使用t检验和协方差分析，89名大叶地区的CN参与者。线性回归分析用于研究WMH与认知障碍之间的关联以及淀粉样蛋白与tau负担之间的关联。
结果：在所有地区，与CN和EOnonAD参与者相比，EOAD显示出更高的WMHs，CN和EOnononAD组之间没有显着差异。WMHs越大，认知能力越差。EOAD组Tau负荷与WMH负荷呈正相关。
结论：EOAD始终显示出更高的WMH体积。总的来说,较高的WMHs与EOAD中较差的认知和较高的tau负担相关。
结论：这项研究代表了散发性EOAD中WMHs的综合特征。WMH体积与EOAD中正电子发射断层扫描（PET）的tau负荷有关，提示WMHs与AD负担增加相关。WMH量越大，在全球认知测试中表现越差。与CN和所有脑区的早发性淀粉样蛋白阴性认知障碍（EOnonAD）组相比，EOAD参与者的WMH体积更高。
方法：我们研究了WMH增加在认知和淀粉样蛋白和tau负担中的作用。我们比较了205EOAD的WMH负担，68EOnonAD，使用t检验和协方差分析，89名大叶地区的CN参与者。线性回归分析用于研究WMH与认知障碍之间的关联以及淀粉样蛋白与tau负担之间的关联。
结果：在所有地区，与CN和EOnonAD参与者相比，EOAD显示出更高的WMHs，CN和EOnononAD组之间没有显着差异。WMHs越大，认知能力越差。EOAD组Tau负荷与WMH负荷呈正相关。
结论：EOAD始终显示出更高的WMH体积。总的来说,较高的WMHs与EOAD中较差的认知和较高的tau负担相关。
结论：这项研究代表了散发性EOAD中WMHs的综合特征。WMH体积与EOAD中正电子发射断层扫描（PET）的tau负荷有关，提示WMHs与AD负担增加相关。WMH量越大，在全球认知测试中表现越差。与CN和所有脑区的早发性淀粉样蛋白阴性认知障碍（EOnonAD）组相比，EOAD参与者的WMH体积更高。
