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Abstract：
Increasing evidence has suggested that Corynebacterium kroppenstedtii is associated with some cases of granulomatous mastitis, mostly based on pathology or microbiology. We aimed to identify the clinical characteristics and treatment regimens for granulomatous mastitis with Corynebacterium kroppenstedtii infection. Understanding these clinical features is essential for patient care.
We retrospectively collected data on 201 patients who were pathologically diagnosed with granulomatous mastitis and had microbiological results of either Corynebacterium kroppenstedtii or no bacterial growth and recorded and analysed their demographics, clinical characteristics, and clinical outcomes.
There were 107 patients in the CK group and 94 patients in the negative group. Sinus formation (x2 = 13.028, p = 0.000), time to complete remission at the first treatment period (Z = -3.027, p = 0.002), diameter of breast mass at first-time medical consultancy (Z = -2.539, p = 0.011) and recurrence (x2 = 4.953, p = 0.026) were statistically significant. Age (Z = -1.046, p = 0.295), laterality (x2 = 4.217, p = 0.121), time to presentation since the last delivery (x2 = 0.028, p = 0.868), BMI (Z = -0.947, p = 0.344), lactation time (Z = -1.378, p = 0.168), parity (x2 = 1.799, p = 0.180), gravida (Z = -0.144, p = 0.885), history of lactational mastitis or abscess (x2 = 0.115, p = 0.734), local trauma (x2 = 0.982, p = 0.322), hyperprolactinemia (x2 = 0.706, p = 0.401), erythema nodosum (x2 = 0.292, p = 0.589), and nipple discharge (x2 = 0.281, p = 0.596) did not demonstrate statistical significance. Regarding recurrence related to therapeutic strategy, except for surgery combined with immunosuppressants (x2 = 9.110, p = 0.003), which was statistically significant, none of the other treatment regimens reached statistical significance. The recurrence rate of patients in the CK group using rifampicin in their treatment course was 22.0% (x2 = 4.892, p = 0.027).
Granulomatous mastitis accompanied by Corynebacterium kroppenstedtii more easily forms sinuses and has a higher recurrence rate. Both of the clinical characteristics may indicate that Corynebacterium kroppenstedtii plays an important role in the development and progression of granulomatous mastitis. Lipophilic antibiotics may be essential for granulomatous mastitis with Corynebacterium kroppenstedtii infection.
We retrospectively collected data on 201 patients who were pathologically diagnosed with granulomatous mastitis and had microbiological results of either Corynebacterium kroppenstedtii or no bacterial growth and recorded and analysed their demographics, clinical characteristics, and clinical outcomes.
There were 107 patients in the CK group and 94 patients in the negative group. Sinus formation (x2 = 13.028, p = 0.000), time to complete remission at the first treatment period (Z = -3.027, p = 0.002), diameter of breast mass at first-time medical consultancy (Z = -2.539, p = 0.011) and recurrence (x2 = 4.953, p = 0.026) were statistically significant. Age (Z = -1.046, p = 0.295), laterality (x2 = 4.217, p = 0.121), time to presentation since the last delivery (x2 = 0.028, p = 0.868), BMI (Z = -0.947, p = 0.344), lactation time (Z = -1.378, p = 0.168), parity (x2 = 1.799, p = 0.180), gravida (Z = -0.144, p = 0.885), history of lactational mastitis or abscess (x2 = 0.115, p = 0.734), local trauma (x2 = 0.982, p = 0.322), hyperprolactinemia (x2 = 0.706, p = 0.401), erythema nodosum (x2 = 0.292, p = 0.589), and nipple discharge (x2 = 0.281, p = 0.596) did not demonstrate statistical significance. Regarding recurrence related to therapeutic strategy, except for surgery combined with immunosuppressants (x2 = 9.110, p = 0.003), which was statistically significant, none of the other treatment regimens reached statistical significance. The recurrence rate of patients in the CK group using rifampicin in their treatment course was 22.0% (x2 = 4.892, p = 0.027).
Granulomatous mastitis accompanied by Corynebacterium kroppenstedtii more easily forms sinuses and has a higher recurrence rate. Both of the clinical characteristics may indicate that Corynebacterium kroppenstedtii plays an important role in the development and progression of granulomatous mastitis. Lipophilic antibiotics may be essential for granulomatous mastitis with Corynebacterium kroppenstedtii infection.
摘要：
背景：越来越多的证据表明，克氏棒状杆菌与一些肉芽肿性乳腺炎有关，主要基于病理学或微生物学。我们旨在确定肉芽肿性乳腺炎伴克氏棒状杆菌感染的临床特征和治疗方案。了解这些临床特征对于患者护理至关重要。
方法：我们回顾性地收集了201例经病理诊断为肉芽肿性乳腺炎的患者的数据，这些患者的微生物学结果为克氏棒状杆菌或无细菌生长，并记录和分析了他们的人口统计学特征。临床特征,和临床结果。
结果：CK组107例，阴性组94例。窦形成（x2=13.028，p=0.000），在第一个治疗期完全缓解的时间（Z=-3.027，p=0.002），首次就诊时乳腺肿块直径(Z=-2.539,p=0.011)和复发(x2=4.953,p=0.026)有统计学意义.年龄（Z=-1.046，p=0.295），侧向性(x2=4.217，p=0.121)，自上次交付以来的演示时间(x2=0.028，p=0.868)，BMI（Z=-0.947，p=0.344），泌乳时间（Z=-1.378，p=0.168），奇偶校验（x2=1.799，p=0.180），gravida（Z=-0.144，p=0.885），哺乳期乳腺炎或脓肿病史（x2=0.115，p=0.734），局部创伤（x2=0.982，p=0.322），高泌乳素血症（x2=0.706，p=0.401），结节性红斑（x2=0.292，p=0.589），乳头溢液（x2=0.281，p=0.596）无统计学意义。关于与治疗策略相关的复发，除手术联合免疫抑制剂外（x2=9.110，p=0.003），这在统计上是显著的，其他治疗方案均无统计学意义.CK组患者在治疗过程中使用利福平的复发率为22.0％（x2=4.892，p=0.027）。
结论：肉芽肿性乳腺炎伴发氏棒状杆菌更容易形成鼻窦，复发率更高。这两种临床特征都可能表明克氏棒状杆菌在肉芽肿性乳腺炎的发生发展中起着重要作用。亲脂性抗生素可能是肉芽肿性乳腺炎伴克氏棒状杆菌感染所必需的。
方法：我们回顾性地收集了201例经病理诊断为肉芽肿性乳腺炎的患者的数据，这些患者的微生物学结果为克氏棒状杆菌或无细菌生长，并记录和分析了他们的人口统计学特征。临床特征,和临床结果。
结果：CK组107例，阴性组94例。窦形成（x2=13.028，p=0.000），在第一个治疗期完全缓解的时间（Z=-3.027，p=0.002），首次就诊时乳腺肿块直径(Z=-2.539,p=0.011)和复发(x2=4.953,p=0.026)有统计学意义.年龄（Z=-1.046，p=0.295），侧向性(x2=4.217，p=0.121)，自上次交付以来的演示时间(x2=0.028，p=0.868)，BMI（Z=-0.947，p=0.344），泌乳时间（Z=-1.378，p=0.168），奇偶校验（x2=1.799，p=0.180），gravida（Z=-0.144，p=0.885），哺乳期乳腺炎或脓肿病史（x2=0.115，p=0.734），局部创伤（x2=0.982，p=0.322），高泌乳素血症（x2=0.706，p=0.401），结节性红斑（x2=0.292，p=0.589），乳头溢液（x2=0.281，p=0.596）无统计学意义。关于与治疗策略相关的复发，除手术联合免疫抑制剂外（x2=9.110，p=0.003），这在统计上是显著的，其他治疗方案均无统计学意义.CK组患者在治疗过程中使用利福平的复发率为22.0％（x2=4.892，p=0.027）。
结论：肉芽肿性乳腺炎伴发氏棒状杆菌更容易形成鼻窦，复发率更高。这两种临床特征都可能表明克氏棒状杆菌在肉芽肿性乳腺炎的发生发展中起着重要作用。亲脂性抗生素可能是肉芽肿性乳腺炎伴克氏棒状杆菌感染所必需的。
