Ten adult glioma subjects were identified based on radiological features using standard-of-care MRI prior to any surgical intervention, with subsequent histopathological confirmation of glioma subtype and grade (lower-grade - LGG - and higher-grade - HGG - patients). FPIA was injected as an intravenous bolus injection (range 342-368 MBq), and dynamic PET and MRI data were acquired simultaneously over 66 min.
All patients tolerated the PET/MRI protocol. Three patients were reclassified following resection and histology. Tumour maximum standardised uptake value (SUVmax,60) increased in the order LGG (WHO grade 2) < HGG (WHO grade 3) < HGG (WHO grade 4). The net irreversible solute transfer, Ki, and influx rate constant, K1, were significantly higher in HGG (p < 0.05). Of the MRI variables studied, DCE-MRI-derived extravascular-and-extracellular volume fraction (ve) was high in tumours of WHO grade 4 compared with other grades (p < 0.05). SLC25A20 protein expression was higher in HGG compared with LGG.
Tumoural FPIA PET uptake is higher in HGG compared to LGG. This study supports further investigation of FPIA PET/MRI for brain tumour imaging in a larger patient population.
Clinicaltrials.gov, NCT04097535.
方法:在任何手术干预之前,根据放射学特征使用标准护理MRI确定了10名成人神经胶质瘤受试者。随后的神经胶质瘤亚型和分级的组织病理学确认(低级-LGG-和高级-HGG-患者)。FPIA作为静脉推注注射(范围342-368MBq),动态PET和MRI数据在66分钟内同时采集。
结果:所有患者均耐受PET/MRI方案。切除和组织学检查后,对三名患者进行了重新分类。肿瘤最大标准化摄取值(SUVmax,60)按LGG(WHO2级)
背景:Clinicaltrials.gov,NCT04097535。