关键词: Ghana Global point prevalence survey antimicrobial resistance guideline compliance surgical antimicrobial prophylaxis surgical site infection

Mesh : Adult Humans Child Ghana Drug Resistance, Microbial Anti-Infective Agents / therapeutic use Anti-Bacterial Agents / therapeutic use Hospitals, Teaching Surgical Wound Infection / drug therapy prevention & control

来  源:   DOI:10.1080/21548331.2023.2241344

Abstract:
UNASSIGNED: There is a need to assess the quality of antimicrobial prescribing in hospitals as a first step toward improving future prescribing to reduce antimicrobial resistance (AMR). This is in line with Ghana\'s National Action Plan.
UNASSIGNED: A point prevalence survey of antimicrobial use was undertaken at the adult medical, surgical, and pediatric wards of Tamale Teaching Hospital using the standardized Global Point Prevalence Survey (GPPS) tool. Key target areas include adherence to current guidelines, limiting the prescribing of \'Watch\' antibiotics with their greater resistance potential, and limiting the prescribing of antibiotics post-operatively to prevent surgical site infections (SSIs).
UNASSIGNED: Out of 217 patients\' medical records assessed, 155 (71.4%) patients were prescribed antimicrobials. The rates were similar among children (73.9%) and adults (70.3%). Most of the antibiotics prescribed were in the WHO \'Watch\' group (71.0%) followed by those in the \'Access\' group (29%). Out of the 23 cases indicated for surgical antimicrobial prophylaxis to prevent SSIs, the majority (69.6%) were given doses for more than 1 day, with none receiving a single dose. This needs addressing to reduce AMR and costs. Guideline compliance with the current Ghanaian Standard Treatment Guidelines (GSTG) for managing infections was also low (28.7%). The type of indication was the only independent predictor of guideline compliance (aOR = 0.013 CI 0.001-0.127, p-value = 0.001).
UNASSIGNED: Given current concerns with antimicrobial prescribing in this hospital, deliberate efforts must be made to improve the appropriateness of prescribing to reduce AMR via targeted antimicrobial stewardship programs.
摘要:
有必要评估医院抗菌药物处方的质量,作为改善未来处方以减少抗菌素耐药性(AMR)的第一步。这符合加纳的国家行动计划。
在成人医学中进行了抗菌药物使用的点患病率调查,外科,和Tamale教学医院的儿科病房使用标准化的全球点患病率调查(GPPS)工具。关键目标领域包括遵守现行准则,限制处方的“观察”抗生素具有更大的耐药性,并限制术后抗生素的处方,以防止手术部位感染(SSIs)。
在评估的217名患者的医疗记录中,155例(71.4%)患者服用抗菌药物。儿童(73.9%)和成人(70.3%)的比率相似。大多数规定的抗生素是WHO“观察”组(71.0%),其次是“访问”组(29%)。在23例接受外科抗菌药物预防以预防SSIs的病例中,大多数(69.6%)的剂量超过1天,没有人接受单剂量。这需要解决以降低AMR和成本。目前加纳管理感染的标准治疗指南(GSTG)的依从性也很低(28.7%)。适应症类型是指南依从性的唯一独立预测因子(aOR=0.013CI0.001-0.127,p值=0.001)。
鉴于该医院目前对抗菌药物处方的担忧,必须做出深思熟虑的努力,通过有针对性的抗菌药物管理计划提高处方减少AMR的适宜性.
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