PDF(Pubmed)
Abstract：
Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to diphtheria toxin. C. ulcerans is widely distributed in the environment and is considered one of the most harmful pathogens to livestock and wildlife. Infection with C. ulcerans can cause respiratory or nonrespiratory symptoms in patients. Recently, the microorganism has been increasingly recognized as an emerging zoonotic agent of diphtheria-like illness in Japan. To clarify the overall clinical characteristics, treatment-related factors, and outcomes of C. ulcerans infection, we analyzed 34 cases of C. ulcerans that occurred in Japan during 2001-2020. During 2010-2020, the incidence rate of C. ulcerans infection increased markedly, and the overall mortality rate was 5.9%. It is recommended that adults be vaccinated with diphtheria toxoid vaccine to prevent the spread of this infection.
摘要：
溃疡棒状杆菌是与白喉杆菌密切相关的细菌。一些溃疡梭菌菌株产生类似于白喉毒素的毒素。C.溃疡广泛分布于环境中，被认为是对牲畜和野生生物最有害的病原体之一。溃疡梭菌感染可引起患者的呼吸道或非呼吸道症状。最近,在日本，这种微生物越来越被认为是白喉样疾病的新兴人畜共患因子。为了阐明总体临床特征，治疗相关因素，以及溃疡梭菌感染的结果，我们分析了2001-2020年在日本发生的34例C.溃疡。2010-2020年，溃疡梭菌感染发病率明显上升，总死亡率为5.9%。建议成年人接种白喉类毒素疫苗，以防止这种感染的传播。
