PDF(Pubmed)
Abstract：
UNASSIGNED: Alzheimer\'s disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor.
UNASSIGNED: To investigate the association between APOE4 and BCHE-K as a risk factor for AD.
UNASSIGNED: We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele.
UNASSIGNED: Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the meta-analysis. The quality of the evidence is moderate. There is a positive E4-K association for subjects with AD as shown by the odds ratio of 3.43. The chi-square meta test, which measures the probability that the E4-K association is due to chance, has an odds ratio of 6.155, indicating that the E4-K association is not a random event. The odds ratio of an E4-K association in subjects with AD increases to OR 4.46 for the 65- to 75-year-old group and OR 4.15 for subjects older than 75 years. The probability that the E4-K association is due to chance is ruled out by chi-square meta test values of OR 8.638 and OR 9.558.
UNASSIGNED: The synergy between APOE4 and BCHE-K is a risk factor for late-onset AD.
UNASSIGNED: To investigate the association between APOE4 and BCHE-K as a risk factor for AD.
UNASSIGNED: We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele.
UNASSIGNED: Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the meta-analysis. The quality of the evidence is moderate. There is a positive E4-K association for subjects with AD as shown by the odds ratio of 3.43. The chi-square meta test, which measures the probability that the E4-K association is due to chance, has an odds ratio of 6.155, indicating that the E4-K association is not a random event. The odds ratio of an E4-K association in subjects with AD increases to OR 4.46 for the 65- to 75-year-old group and OR 4.15 for subjects older than 75 years. The probability that the E4-K association is due to chance is ruled out by chi-square meta test values of OR 8.638 and OR 9.558.
UNASSIGNED: The synergy between APOE4 and BCHE-K is a risk factor for late-onset AD.
摘要：
■阿尔茨海默病（AD）有几个危险因素。APOE4是主要的，有人认为，作为一个危险因素，它与BCHE-K之间可能存在协同作用。
■探讨APOE4和BCHE-K作为AD危险因素的相关性。
■我们搜索了PubMed，WebofScience,Embase,和Scopus于2021年8月8日进行了分析APOE4和BCHE-K与AD的关联的研究。随机效应模型按年龄组进行Meta分析。用荟萃分析数据进行卡方,以验证所发现的效应是否不仅与E4等位基因相关。
■21项研究纳入了6,853名受试者（3,528名AD和3,325名对照）的荟萃分析。证据质量适中。如比值比3.43所示,患有AD的受试者存在正E4-K关联。卡方元检验，它测量E4-K关联归因于偶然的概率，比值比为6.155，表明E4-K关联不是随机事件。在患有AD的受试者中，E4-K关联的比值比在65至75岁的组中增加到OR4.46，在75岁以上的受试者中增加到OR4.15。E4-K关联归因于偶然性的概率通过卡方元检验值OR8.638和OR9.558排除。
■APOE4与BCHE-K之间的协同作用是晚发性AD的危险因素。
■探讨APOE4和BCHE-K作为AD危险因素的相关性。
■我们搜索了PubMed，WebofScience,Embase,和Scopus于2021年8月8日进行了分析APOE4和BCHE-K与AD的关联的研究。随机效应模型按年龄组进行Meta分析。用荟萃分析数据进行卡方,以验证所发现的效应是否不仅与E4等位基因相关。
■21项研究纳入了6,853名受试者（3,528名AD和3,325名对照）的荟萃分析。证据质量适中。如比值比3.43所示,患有AD的受试者存在正E4-K关联。卡方元检验，它测量E4-K关联归因于偶然的概率，比值比为6.155，表明E4-K关联不是随机事件。在患有AD的受试者中，E4-K关联的比值比在65至75岁的组中增加到OR4.46，在75岁以上的受试者中增加到OR4.15。E4-K关联归因于偶然性的概率通过卡方元检验值OR8.638和OR9.558排除。
■APOE4与BCHE-K之间的协同作用是晚发性AD的危险因素。
