{Reference Type}: Systematic Review
{Title}: Confirmed Synergy Between the ɛ4 Allele of Apolipoprotein E and the Variant K of Butyrylcholinesterase as a Risk Factor for Alzheimer's Disease: A Systematic Review and Meta-Analysis.
{Author}: Ratis RC;Dacoregio MI;Simão-Silva DP;Mateus RP;Machado LPB;Bonini JS;da Silva WCFN;
{Journal}: J Alzheimers Dis Rep
{Volume}: 7
{Issue}: 1
{Year}: 2023
暂无{DOI}: 10.3233/ADR-220084
{Abstract}: UNASSIGNED: Alzheimer's disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor.
UNASSIGNED: To investigate the association between APOE4 and BCHE-K as a risk factor for AD.
UNASSIGNED: We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele.
UNASSIGNED: Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the meta-analysis. The quality of the evidence is moderate. There is a positive E4-K association for subjects with AD as shown by the odds ratio of 3.43. The chi-square meta test, which measures the probability that the E4-K association is due to chance, has an odds ratio of 6.155, indicating that the E4-K association is not a random event. The odds ratio of an E4-K association in subjects with AD increases to OR 4.46 for the 65- to 75-year-old group and OR 4.15 for subjects older than 75 years. The probability that the E4-K association is due to chance is ruled out by chi-square meta test values of OR 8.638 and OR 9.558.
UNASSIGNED: The synergy between APOE4 and BCHE-K is a risk factor for late-onset AD.