PDF(Pubmed)
Abstract：
Reconstruction of posterior lamellar eyelids remains challenging due to their delicate structure, highly specialized function, and cosmetic concerns. Current clinically available techniques for posterior lamellar reconstruction mainly focus on reconstructing the contour of the eyelids. However, the posterior lamella not only provides structural support for the eyelid but also offers a smooth mucosal surface to facilitate globe movement and secrete lipids to maintain ocular surface homeostasis. Bioengineered posterior lamellar substitutes developed via acellular or cellular approaches have shown promise as alternatives to current therapies and encouraging outcomes in animal studies and clinical conditions. Here, we provide a brief reference on the current application of autografts, biomaterials, and tissue-engineered substitutes for posterior lamellar eyelid reconstruction. We also shed light on future challenges and directions for eyelid regeneration strategies and offer perspectives on transitioning replacement strategies to regeneration strategies for eyelid reconstruction in the future.
摘要：
后板层眼睑的重建由于其精致的结构仍然具有挑战性，高度专业化的功能，和化妆品问题。目前临床上可用的后板层重建技术主要集中在重建眼睑的轮廓上。然而,后薄层不仅为眼睑提供结构支持，而且提供光滑的粘膜表面以促进眼球运动并分泌脂质以维持眼表稳态。通过无细胞或细胞方法开发的生物工程后层状替代品已显示出有望作为当前疗法的替代品，并在动物研究和临床条件下取得令人鼓舞的结果。这里,我们提供了当前自体移植物应用的简要参考，生物材料,和组织工程替代后板层眼睑重建。我们还阐明了眼睑再生策略的未来挑战和方向，并提供了将替代策略过渡到未来眼睑重建再生策略的观点。
