Abstract：
Aspirin-exacerbated respiratory disease (AERD) consists of chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and hypersensitivity to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs). Asthma is associated with increased risk of atherosclerotic cardiovascular diseases (ASCVD). However, there is lack of data on association between AERD and ASCVD.
To investigate the relationship between AERD and subsequent risk of ASCVD.
An algorithm to find patients with AERD was generated and validated through chart review at our home institution. This algorithm was applied to a national insurance claims database to obtain data for a retrospective cohort study. Demographic and comorbidity data were obtained for propensity matching. Several methods of analysis were performed on the data.
A total of 571 patients met criteria for AERD; 3909 met criteria for asthma, CRSwNP, and no allergy to aspirin or NSAIDs (group 1); and 75,050 met criteria for asthma, CRS without nasal polyps, and no allergy to aspirin or NSAIDs (group 2). After covariate adjustment, AERD was significantly associated with ASCVD, including severe ASCVD, over groups 1 and 2 regardless of asthma severity.
Patients with AERD are at higher risk of ASCVD than patients with asthma and CRSwNP or CRS without nasal polyps, underscoring the need for early ASCVD screening and a consideration for aspirin desensitization or use of a nonaspirin antiplatelet agent in the setting of AERD and comorbid ASCVD.
To investigate the relationship between AERD and subsequent risk of ASCVD.
An algorithm to find patients with AERD was generated and validated through chart review at our home institution. This algorithm was applied to a national insurance claims database to obtain data for a retrospective cohort study. Demographic and comorbidity data were obtained for propensity matching. Several methods of analysis were performed on the data.
A total of 571 patients met criteria for AERD; 3909 met criteria for asthma, CRSwNP, and no allergy to aspirin or NSAIDs (group 1); and 75,050 met criteria for asthma, CRS without nasal polyps, and no allergy to aspirin or NSAIDs (group 2). After covariate adjustment, AERD was significantly associated with ASCVD, including severe ASCVD, over groups 1 and 2 regardless of asthma severity.
Patients with AERD are at higher risk of ASCVD than patients with asthma and CRSwNP or CRS without nasal polyps, underscoring the need for early ASCVD screening and a consideration for aspirin desensitization or use of a nonaspirin antiplatelet agent in the setting of AERD and comorbid ASCVD.
摘要：
背景：阿司匹林加重呼吸道疾病（AERD）包括慢性鼻-鼻窦炎伴鼻息肉（CRSwNP），哮喘,和对阿司匹林或非甾体抗炎药（NSAIDs）的超敏反应。哮喘与动脉粥样硬化性心血管疾病（ASCVD）的风险增加有关。然而,缺乏关于AERD和ASCVD之间关联的数据.
目的：探讨AERD与ASCVD风险的关系。
方法：在我们的家庭机构通过图表审查生成并验证了发现AERD患者的算法。将该算法应用于国家保险索赔数据库，以获得回顾性队列研究的数据。获得人口统计和合并症数据以进行倾向匹配。对数据进行了几种分析方法。
结果：共有571名患者符合AERD标准，3909符合哮喘标准，CRSwNP，对阿司匹林或NSAIDs无过敏（第1组），75,050符合哮喘标准，CRS无鼻息肉,无阿司匹林或NSAIDs过敏（第2组）。在协变量调整后，AERD与ASCVD显著相关,包括严重的ASCVD,超过第1组和第2组，无论哮喘严重程度如何。
结论：AERD患者发生ASCVD的风险高于哮喘和CRS伴或不伴鼻息肉的患者，强调早期ASCVD筛查的必要性,以及在AERD和ASCVD合并症的情况下考虑阿司匹林脱敏或使用非阿司匹林抗血小板药物.
目的：探讨AERD与ASCVD风险的关系。
方法：在我们的家庭机构通过图表审查生成并验证了发现AERD患者的算法。将该算法应用于国家保险索赔数据库，以获得回顾性队列研究的数据。获得人口统计和合并症数据以进行倾向匹配。对数据进行了几种分析方法。
结果：共有571名患者符合AERD标准，3909符合哮喘标准，CRSwNP，对阿司匹林或NSAIDs无过敏（第1组），75,050符合哮喘标准，CRS无鼻息肉,无阿司匹林或NSAIDs过敏（第2组）。在协变量调整后，AERD与ASCVD显著相关,包括严重的ASCVD,超过第1组和第2组，无论哮喘严重程度如何。
结论：AERD患者发生ASCVD的风险高于哮喘和CRS伴或不伴鼻息肉的患者，强调早期ASCVD筛查的必要性,以及在AERD和ASCVD合并症的情况下考虑阿司匹林脱敏或使用非阿司匹林抗血小板药物.
