Abstract：
Severe nerve injuries can be treated with electrical stimulation and stem cell therapies, but little is known about the potential benefits of combining these two treatments. In an effort to investigate this combination, we conducted a study to evaluate the effectiveness of electrical stimulation and Schwann-like cell transplantation in female Wistar albino rats. Our study consisted of five groups of rats: a sham group, an injury group, an electrical stimulation group, a Schwann-like cell group, and a combination group. The experimental groups received electrical stimulation, Schwann-like cell transplantation, or both. The animals sciatic function index was evaluated during a 6-week recovery period, and nerve conduction velocity, wet muscle mass, and nerve tissues were also analyzed. The results of the study showed that all experimental groups had a faster functional recovery compared to the injury group, although the difference between groups was not statistically significant. Both the combination group and the Schwann-like cell transplantation group had a higher nerve conduction velocity compared to the other experimental groups. However, there was no significant difference between the combination and Schwann-like cell transplantation groups. Nonetheless, histological analysis showed a better axonal reorganization in the combination group. The study provides preliminary evidence of the potential benefits of combining electrical stimulation and Schwann-like cell transplantation in treating severe nerve injuries. However, further studies with larger sample sizes are needed to confirm these findings and optimize the treatment parameters.
摘要：
严重的神经损伤可以通过电刺激和干细胞治疗来治疗，但对这两种治疗方法的潜在益处知之甚少。为了研究这种组合，我们进行了一项研究，以评估电刺激和雪旺样细胞移植在雌性Wistar白化病大鼠中的有效性。我们的研究由五组大鼠组成：假手术组，受伤组，一个电刺激组，一个类似施万的细胞群，和一个组合组。实验组接受电刺激,雪旺样细胞移植,或者两者兼而有之。在6周的恢复期内评估动物坐骨神经功能指数，和神经传导速度,湿肌肉质量，和神经组织也进行了分析。研究结果表明,与损伤组相比,各实验组的功能恢复较快,尽管组间差异无统计学意义。与其他实验组相比，联合组和雪旺样细胞移植组均具有更高的神经传导速度。然而,组合与施万样细胞移植组之间无显著差异。尽管如此，组织学分析表明，组合组中轴突重组更好。该研究提供了电刺激和雪旺样细胞移植联合治疗严重神经损伤的潜在益处的初步证据。然而,需要更大样本量的进一步研究来证实这些发现并优化治疗参数.
