Abstract：
Oxidative stress and tissue damage (OSD) play a pivotal role as an early-stage process in chronic disease pathogenesis. However, there has been little research to better understand the temporal (χρόνος[chronos]) dimensions of OSD process associated with environmental (non-genetic, including behaviors/lifestyle) and/or occupational stressors, like night shift work. OSD processes have recently attracted attention in relation to time-resolved external stressor trajectories in personalized medicine (prevention) initiatives, as they seem to interact with circadian clock systems towards the improved delineation of the early stages of (chronic) disease process.
This work critically reviewed human studies targeting the temporal dynamics of OSD and circadian clock system\'s activity in response to environmental/occupational stressors; the case of night shift work was examined.
Being a key stressor influencing OSD processes and circadian rhythm, night shift work was evaluated as part of a scoping review of research in OSD, including inflammatory and metabolic processes to determine the extent of OSD research undertaken in human populations, methodologies, tools and biomarkers used and the extent that the temporal dimensions of exposure and biological effect(s) were accounted for. Online databases were searched for papers published from 2000 onwards, resulting in the selection of 53 original publications.
The majority of studies (n = 41) took place in occupational settings, while the rest were conducted in the general population or patient groups. Most occupational studies targeted outcomes of oxidative stress/damage (n = 19), followed by the combination of OSD with inflammatory response (n = 10), and studies focused on metabolic outcomes (n = 12). Only a minor fraction of the studies measured biomarkers related to circadian rhythm, such as, melatonin, its metabolite, or cortisol. Night shift work was associated with select biomarkers of OSD and inflammation, albeit with mixed results. Although much progress in delineating the biological mechanisms of OSD process has been made, an equally thorough investigation on the temporal trajectory of OSD processes as triggered by environmental/occupational stressors in human studies has yet to fully evolve.
This work critically reviewed human studies targeting the temporal dynamics of OSD and circadian clock system\'s activity in response to environmental/occupational stressors; the case of night shift work was examined.
Being a key stressor influencing OSD processes and circadian rhythm, night shift work was evaluated as part of a scoping review of research in OSD, including inflammatory and metabolic processes to determine the extent of OSD research undertaken in human populations, methodologies, tools and biomarkers used and the extent that the temporal dimensions of exposure and biological effect(s) were accounted for. Online databases were searched for papers published from 2000 onwards, resulting in the selection of 53 original publications.
The majority of studies (n = 41) took place in occupational settings, while the rest were conducted in the general population or patient groups. Most occupational studies targeted outcomes of oxidative stress/damage (n = 19), followed by the combination of OSD with inflammatory response (n = 10), and studies focused on metabolic outcomes (n = 12). Only a minor fraction of the studies measured biomarkers related to circadian rhythm, such as, melatonin, its metabolite, or cortisol. Night shift work was associated with select biomarkers of OSD and inflammation, albeit with mixed results. Although much progress in delineating the biological mechanisms of OSD process has been made, an equally thorough investigation on the temporal trajectory of OSD processes as triggered by environmental/occupational stressors in human studies has yet to fully evolve.
摘要：
背景：氧化应激和组织损伤（OSD）作为慢性疾病发病机制的早期过程中起着关键作用。然而,很少有研究来更好地了解与环境(非遗传，包括行为/生活方式)和/或职业压力源，比如夜班工作。OSD过程最近引起了人们对个性化医疗（预防）计划中时间分辨的外部压力源轨迹的关注，因为它们似乎与生物钟系统相互作用，以改善（慢性）疾病过程早期阶段的轮廓。
目的：这项工作严格审查了针对OSD的时间动态和昼夜节律系统响应环境/职业应激源的活动的人类研究；检查了夜班工作的情况。
方法：作为影响OSD过程和昼夜节律的关键压力源，夜班工作作为OSD研究范围审查的一部分进行了评估，包括炎症和代谢过程，以确定在人群中进行的OSD研究的程度，方法论，使用的工具和生物标志物，以及暴露的时间维度和生物效应的程度。在网上数据库中搜索了从2000年开始发表的论文，结果选择了53种原始出版物。
结论：大多数研究（n=41）发生在职业环境中，其余的在普通人群或患者组中进行。大多数职业研究针对氧化应激/损伤的结果（n=19），其次是OSD与炎症反应的组合（n=10），研究集中在代谢结果(n=12)。只有一小部分研究测量了与昼夜节律相关的生物标志物，例如,褪黑激素,它的代谢产物,或者皮质醇.夜班工作与OSD和炎症的选择性生物标志物相关，尽管结果好坏参半。尽管在描述OSD过程的生物学机制方面已经取得了很大进展，对人类研究中由环境/职业压力源引发的OSD过程的时间轨迹进行同样彻底的调查尚未完全发展。
目的：这项工作严格审查了针对OSD的时间动态和昼夜节律系统响应环境/职业应激源的活动的人类研究；检查了夜班工作的情况。
方法：作为影响OSD过程和昼夜节律的关键压力源，夜班工作作为OSD研究范围审查的一部分进行了评估，包括炎症和代谢过程，以确定在人群中进行的OSD研究的程度，方法论，使用的工具和生物标志物，以及暴露的时间维度和生物效应的程度。在网上数据库中搜索了从2000年开始发表的论文，结果选择了53种原始出版物。
结论：大多数研究（n=41）发生在职业环境中，其余的在普通人群或患者组中进行。大多数职业研究针对氧化应激/损伤的结果（n=19），其次是OSD与炎症反应的组合（n=10），研究集中在代谢结果(n=12)。只有一小部分研究测量了与昼夜节律相关的生物标志物，例如,褪黑激素,它的代谢产物,或者皮质醇.夜班工作与OSD和炎症的选择性生物标志物相关，尽管结果好坏参半。尽管在描述OSD过程的生物学机制方面已经取得了很大进展，对人类研究中由环境/职业压力源引发的OSD过程的时间轨迹进行同样彻底的调查尚未完全发展。
