Abstract：
The bulge region, a reservoir of multipotent stem cells, is possibly responsible for tumorigenesis. NF-κB-inducing kinase (NIK) is a kinase involved in the activation of the noncanonical NF-κB pathway and exhibits positive staining in tumor cells. However, whether high expression of NIK can result in tumorigenesis has not been reported in published papers. By establishing Nik-coe (Nik-stopF/F crossed with Chat-cre) and Nik-soe (Nik-stopF/F crossed with Sox9-cre) mice, we found that overexpression of Nik in the bulge region of hair follicles induced hair follicle loss and tumorigenesis. Furthermore, RNA sequencing, proteomic and phosphopeptide analyses revealed that multiple cancer pathways are involved in tumor formation. Taken together, these findings indicate that constitutive activation of Nik in the bulge region induces tumorigenesis.
摘要：
凸起区域，一个多能干细胞的储库，可能是肿瘤发生的原因.NF-κB诱导激酶（NIK）是一种参与非常规NF-κB途径激活的激酶，在肿瘤细胞中呈阳性染色。然而,NIK的高表达是否会导致肿瘤发生尚未在发表的论文中报道。通过建立Nik-coe（Nik-stopF/F与Chat-cre杂交）和Nik-soe（Nik-stopF/F与Sox9-cre杂交）小鼠，我们发现Nik在毛囊隆起区的过表达会导致毛囊丢失和肿瘤发生。此外，RNA测序，蛋白质组和磷酸肽分析显示，多种癌症途径参与肿瘤的形成。一起来看,这些发现表明Nik在凸起区域的组成型激活诱导了肿瘤发生。
